Evidence map›Paper›PMID 32984663›Full record

ReviewCurrent opinion in systems biology2017

Controlling cell size through sizer mechanisms.

Giuseppe Facchetti, Fred Chang, Martin Howard

Abstract readReview
In one paragraph

Review in Current opinion in systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Article
  3. Stress-dependent growth in breast cancer arises from a mechano-osmotic coupling and cell-sizing checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Clocks and Dominoes: Timing Mechanisms of Embryogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Nonlinear memory in cell-division dynamics across species.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Big1 is a cell cycle regulator linking cell size to basal body number.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Mechanical control of cell proliferation patterns in growing tissues.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giuseppe FacchettiComputational and Systems Biology, John Innes Centre, Norwich, NR4 7UH, United Kingdom.
Fred ChangDept. of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, 94143, USA.
Martin HowardComputational and Systems Biology, John Innes Centre, Norwich, NR4 7UH, United Kingdom.

Funding

Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9773
6 · The paper itself

Abstract

Cell size is partly determined through coordination between cell growth and division. How this coordination is achieved mechanistically remains mostly unknown. However, quantitative experiments together with computational modelling have reinvigorated the field and are elucidating underlying molecular processes. Size homeostasis may be achieved through different modes of regulation, including "sizers", "adders" and "timers." For sizer regulation, the cell division cycle does not proceed until a minimal size has been reached, requiring that the cell monitors its own size. Here, we highlight progress in defining sizer mechanisms in fission and budding yeasts showing how accumulation or dilution of key molecules can be used to monitor cell size during growth. We also discuss a potential role for sizers in bacterial size control.

Indexed as

Cell cycleCell size homeostasisSizer mechanism

Identifiers

PMID32984663
PMCPMC7493432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.