Evidence map›Paper›PMID 32984661›Full record

ArticleCurrent opinion in systems biology2020

Real-time, personalized medicine through wearable sensors and dynamic predictive modeling: a new paradigm for clinical medicine.

Jonathan Tyler, Sung Won Choi, Muneesh Tewari

Open access · hybridAbstract read
In one paragraph

Article in Current opinion in systems biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 86 citations in OpenAlex.

  1. Review
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  7. Preparing Wearable Data for AI-Powered Mood and Compliance Prediction in HCT Patients and Caregivers.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2024
    Article
  8. Article
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  10. Review
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  14. Article
  15. Review
  16. Analysis of wearable time series data in endocrine and metabolic research.Current opinion in endocrine and metabolic research · 2022
    Review
  17. Observational
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jonathan TylerDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Sung Won ChoiDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Muneesh TewariDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
University of Michigan · US

Funding

Training Program in Molecular HematologyT32HL007622 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI, Jordan A. Shavit · 1986 to 2026
$9.2M
Phase I/II clinical trial of HDAC inhibition for GVHD prevention in children, adolescents, and young adultsR01CA249211 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOI, SUNG WON · 2020 to 2024
$2.2M
Roadmap 2.0: A randomized controlled trial using a technology-mediated platform in family caregivers of BMT patientsR01HL146354 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOI, SUNG WON · 2019 to 2023
$1.8M
NCI NIH HHS R01 CA249211NHLBI NIH HHS R01 HL146354NHLBI NIH HHS T32 HL007622
6 · The paper itself

Abstract

Accurately predicting the onset and course of a disease in an individual is a major unmet challenge in medicine due to the complex and dynamic nature of disease progression. Continuous data from wearable technologies and biomarker data with a fine time resolution provide a unique opportunity to learn more about disease evolution and to usher in a new era of personalized and real-time medicine. Herein, we propose the potential of real-time, continuously measured physiological data as a noninvasive biomarker approach for detecting disease transitions, using allogeneic hematopoietic stem cell transplant (HCT) patient care as an example. Additionally, we review a recent computational technique, the landscape dynamic network biomarker method, that uses biomarker data to identify transition states in disease progression and explore how to use it with both biomarker and physiological data for earlier detection of graft-versus-host disease specifically. Throughout, we argue that increased collaboration across multiple fields is essential to realizing the full potential of wearable and biomarker data in a new paradigm of personalized and real-time medicine.

Identifiers

PMID32984661
PMCPMC7515448
OpenAlexW3041908448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.