ArticleHeliyon2020
Individual and combined bioscore model of presepsin, procalcitonin, and high sensitive C - reactive protein as biomarkers for early diagnosis of paediatric sepsis.
Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Diagnostic performance of procalcitonin and presepsin in sepsis: a systematic review and meta-analysis.BMC emergency medicine · 2025Pooled it
- Presepsin as a diagnostic biomarker for sepsis across neonates, children, and adults: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.Critical care medicine · 2022Pooled it
- A Novel Composite Bioscore Integrating Biomarkers, Clinical Scores, and Comorbidity Indices for Prognostic Stratification in Sepsis.Journal of inflammation research · 2026Article
- Evaluation of procalcitonin as a marker of bacterial sepsis in children in Owerri, Nigeria.African health sciences · 2025Article
- Construction and efficacy evaluation of a model for early diagnosis of pediatric sepsis based on LASSO-logistic regression.Frontiers in pediatrics · 2025Article
- Decreasing Procalcitonin and Its Ratio to Albumin Predict Mortality in Patients with Abdominal Sepsis.Journal of inflammation research · 2025Article
- Study of some biological markers in cord blood of preterm and term infants and their association with neonatal sepsis.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Disease burden comparison and associated risk factors of early- and late-onset neonatal sepsis in China and the USA, 1990-2019.Global health action · 2024Article
- A study on bacteriological profile in suspected cases of neonatal sepsis and its correlation with various biomarkers in the rural population of a university hospital.Journal of family medicine and primary care · 2023Article
- Presepsin as a diagnostic marker of sepsis in children and adolescents: a short critical update.Acta bio-medica : Atenei Parmensis · 2023Review
- The role of presepsin in pediatric patients with oncological and hematological diseases experiencing febrile neutropenia.Scientific reports · 2023Article
- The evolving value of older biomarkers in the clinical diagnosis of pediatric sepsis.Pediatric research · 2023Review
- Article
- The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review.International journal of molecular sciences · 2021Review
- Diagnostic Value of sIL-2R, TNF-α and PCT for Sepsis Infection in Patients With Closed Abdominal Injury Complicated With Severe Multiple Abdominal Injuries.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPaediatric sepsis remains a major public health problem with significant morbidity and mortality especially in developing countries. Clinical symptoms associated with sepsis are unreliable and laboratory parameters unspecific, making an early diagnosis of paediatric sepsis difficult. The lack of definitive biomarker(s) for early diagnosis of sepsis further leads to the misuse of antibiotics. Diagnosis based on a single biomarker does not provide adequate accuracy. Subsequently, combining multiple biomarkers into a single score will help clinicians make a better diagnostic judgment.
aimsThis study for the first time evaluated the individual and combined diagnostic accuracy of procalcitonin (PCT), presepsin (sCD14-ST) and high sensitive C-reactive protein (hs-CRP) using a Bioscore model. MATERIALS AND
methodsIn a case control study conducted at the Paediatric Emergency Unit (PEU) and the Mother and Baby Unit (MBU) of Komfo Anokye Teaching Hospital (KATH), sixty (60) paediatric subjects aged zero to six (0-6) years, were diagnosed with sepsis using case-definition by the national neonatal bloodstream infection surveillance and Pediatric Sepsis Consensus Congress. Thirty (30) other paediatric subjects, aged and sex matched without sepsis or inflammatory conditions were used as controls. One-time blood sample was taken at the time of admission for blood culture and measurement of PCT, hs-CRP, and presepsin by ELISA. The Statistical Package for Social Sciences (SPSS release 20.0, Copyright ©SPSS Inc.) was used for analysis.
resultsOut of the sixty septic paediatric subjects, 14 patients (23.3%) had positive blood cultures (LCS) and 46 (76%) had negative for blood cultures (CS).
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