ArticleEuropean journal of radiology open2020
36M-pixel synchrotron radiation micro-CT for whole secondary pulmonary lobule visualization from a large human lung specimen.
Article in European journal of radiology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review of image segmentation techniques for biomedical micro-CT: from laboratory absorption imaging to synchrotron phase-contrast.Npj imaging · 2026Review
- A lung CT vision foundation model facilitating disease diagnosis and medical imaging.Nature communications · 2025Article
- Advancements in High-Resolution Computed Tomography: Revolutionising Bone Health Micro-Research.Bioengineering (Basel, Switzerland) · 2025Article
- Superimposed Wavefront Imaging of Diffraction-enhanced X-rays: sparsity-aware CT reconstruction from limited-view projections.International journal of computer assisted radiology and surgery · 2025Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- A multiscale X-ray phase-contrast tomography dataset of a whole human left lung.Scientific data · 2022Article
- A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale.Journal of synchrotron radiation · 2022Article
- From Macroscopy to Ultrastructure: An Integrative Approach to Pulmonary Pathology.Frontiers in medicine · 2022Article
- Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography.Nature methods · 2021Article
- Volumetric Imaging of Lung Tissue at Micrometer Resolution: Clinical Applications of Micro-CT for the Diagnosis of Pulmonary Diseases.Diagnostics (Basel, Switzerland) · 2021Review
- Special Issue: Chest Imaging 2021.European journal of radiology open · 2021Article
- Accurately Locating Metastatic Foci in Lymph Nodes With Lugol's Iodine-Enhanced Micro-CT Imaging.Frontiers in oncology · 2021Article
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5 authors.
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Abstract
A micro-CT system was developed using a 36M-pixel digital single-lens reflex camera as a cost-effective mode for large human lung specimen imaging. Scientific grade cameras used for biomedical x-ray imaging are much more expensive than consumer-grade cameras. During the past decade, advances in image sensor technology for consumer appliances have spurred the development of biomedical x-ray imaging systems using commercial digital single-lens reflex cameras fitted with high megapixel CMOS image sensors. This micro-CT system is highly specialized for visualizing whole secondary pulmonary lobules in a large human lung specimen. The secondary pulmonary lobule, a fundamental unit of the lung structure, reproduces the lung in miniature. The lung specimen is set in an acrylic cylindrical case of 36 mm diameter and 40 mm height. A field of view (FOV) of the micro-CT is 40.6 mm wide × 15.1 mm high with 3.07 μm pixel size using offset CT scanning for enlargement of the FOV. We constructed a 13,220 × 13,220 × 4912 voxel image with 3.07 μm isotropic voxel size for three-dimensional visualization of the whole secondary pulmonary lobule. Furthermore, synchrotron radiation has proved to be a powerful high-resolution imaging tool. This micro-CT system using a single-lens reflex camera and synchrotron radiation provides practical benefits of high-resolution and wide-field performance, but at low cost.
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