ArticleFrontiers in medicine2020
Impact of Gut Microbiome on Hypertensive Patients With Low-Salt Intake: Shika Study Results.
Article in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Gut Microbiota as a Mediator of Dietary Salt Effects on Blood Pressure.International journal of molecular sciences · 2026Review
- Gut microbiota-derived polyamine pathways associated with mean blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association of oral frailty and gut microbiota with hypertension: cross-sectional results in the Shika study.Frontiers of medicine · 2025Article
- Salt sensitivity potentiates high-salt diet-induced intestinal barrier disruption and gut microbiome dysbiosis in rats.Frontiers in microbiology · 2025Article
- The immune-microbiome axis in salt-sensitive hypertension: a focus on renal and neural mechanisms.Frontiers in physiology · 2025Review
- Prediction and causal inference of hyperuricemia using gut microbiota.Scientific reports · 2024Article
- The association between gut microbiome and hypertension varies according to enterotypes: a Korean study.Frontiers in microbiomes · 2023Article
- Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results.Frontiers in cellular and infection microbiology · 2023Article
- Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salt intake is one of the most important environmental factors impacting hypertension onset. Meanwhile, the potential roles of the gut microbiome (GM) in altering the health status of hosts have drawn considerable attention. Here, we aimed to perform an observational study to investigate the impact of intestinal bacterial flora in hypertensive patients with low-salt or high-salt intake. A total of 239 participants were enrolled, and their gut microbiomes, clinical and demographic details, as well as physiological parameters pertaining to the renin-angiotensin-aldosterone system and inflammatory cytokine profiles, were examined. The participants were classified into four groups based on the presence of different enterotype bacteria, as determined via cluster analysis, and salt intake: low salt/GM enterotype 1, low salt/GM enterotype 2, high salt/GM enterotype 1, and high salt/GM enterotype 2. Results show that the prevalence of hypertension was significantly lower in the low-salt/GM enterotype 2 group (27%) compared to the low salt/GM enterotype 1 group (47%;
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