ArticleFrontiers in cell and developmental biology2020
Single-Cell RNA-Sequencing From Mouse Incisor Reveals Dental Epithelial Cell-Type Specific Genes.
Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Embryonic and postnatal macrophages are necessary for proper tooth development and homeostasis.Nature communications · 2026Article
- Kdf1 missense mutation caused enamel defects by disrupting cell adhesion and Hippo-YAP signaling in dental epithelium.International journal of oral science · 2026Article
- Amelogenin Phosphorylation Affects Key Regulatory Genes in the Enamel Organ.Calcified tissue international · 2026Review
- Spatial Transcriptomics of Early Tooth Morphogenesis in Formalin-fixed Paraffin-embedded Mouse Embryonic Tissue.Journal of visualized experiments : JoVE · 2026Article
- The Absence of Claudin-10 in the Enamel Organ Alters Its Integrity.Journal of dental research · 2026Article
- Enamel decussation pattern originates from directional sliding of ameloblasts.International journal of oral science · 2026Article
- Resolving tooth development at single-cell resolution: advancing dental regeneration.Frontiers in cell and developmental biology · 2026Review
- Article
- Unveiling the dental cellular landscape: A comprehensive review of single-cell RNA sequencing in human dental tissues.The Japanese dental science review · 2025Review
- KMT2D Regulates Tooth Enamel Development.Journal of dental research · 2025Article
- KMT2D regulates tooth enamel development.bioRxiv : the preprint server for biology · 2024Article
- Unraveling the hidden complexity: Exploring dental tissues through single-cell transcriptional profiling.Regenerative therapy · 2024Review
- Single-cell RNA sequencing combined with proteomics of infected macrophages reveals prothymosin-α as a target for treatment of apical periodontitis.Journal of advanced research · 2024Article
- Single-cell RNA-seq analysis of rat molars reveals cell identity and driver genes associated with dental mesenchymal cell differentiation.BMC biology · 2024Article
- Spatiotemporal cell landscape of human embryonic tooth development.Cell proliferation · 2024Article
- Downregulation of connexin 43 is crucial for basal cell alignment in ameloblastoma and odontogenic keratocyst.The Saudi dental journal · 2024Article
- Regulatory role of N-myc downregulated genes in amelogenesis in rats.Journal of molecular histology · 2024Review
- Single-Cell Transcriptomic Analysis of Dental Pulp and Periodontal Ligament Stem Cells.Journal of dental research · 2024Article
- Single-cell census of human tooth development enables generation of human enamel.Developmental cell · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Dental epithelial stem cells give rise to four types of dental epithelial cells: inner enamel epithelium (IEE), outer enamel epithelium (OEE), stratum intermedium (SI), and stellate reticulum (SR). IEE cells further differentiate into enamel-forming ameloblasts, which play distinct roles, and are essential for enamel formation. These are conventionally classified by their shape, although their transcriptome and biological roles are yet to be fully understood. Here, we aimed to use single-cell RNA sequencing to clarify the heterogeneity of dental epithelial cell types. Unbiased clustering of 6,260 single cells from incisors of postnatal day 7 mice classified them into two clusters of ameloblast, IEE/OEE, SI/SR, and two mesenchymal populations. Secretory-stage ameloblasts expressed
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