Evidence map›Paper›PMID 32984332›Full record

ArticleFrontiers in cell and developmental biology2020

Propofol Exposure Disturbs the Differentiation of Rodent Neural Stem Cells via an miR-124-3p/Sp1/Cdkn1b Axis.

Jun Cao, Yan Li, Fanning Zeng, Xiaolei Liu, Tao Tao, Zaisheng Qin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Jun CaoDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yan LiDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fanning ZengDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaolei LiuDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Tao TaoDepartment of Anesthesiology, The Central People's Hospital of Zhanjiang, Zhanjiang, China.
Zaisheng QinDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Southern Medical University · CNCentral People's Hospital of Zhanjiang · CNGuangdong Medical College · CNNanfang Hospital · CNShenzhen Maternity and Child Healthcare Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating studies have indicated that propofol may lead to neurotoxicity and its effect on neural stem cells (NSCs) may play pivotal role in propofol-related neurotoxicity. Previously, we found that propofol could promote NSCs proliferation and could regulate several microRNA expressions. However, the underlying mechanism between microRNAs and NSCs development after propofol exposure is still unclear. Our data first observed that rat primary neural stem cells exposed to propofol exhibited a cell cycle arrest status and an inclination to differentiate into GFAP

Indexed as

cdkn1bcell cycledifferentiationmiR-124-3pneural stem cellspropofolSp1

Identifiers

PMID32984332
PMCPMC7481336
OpenAlexW3081507266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.