Evidence map›Paper›PMID 32984299›Full record

ArticleFrontiers in cell and developmental biology2020

IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation.

Lin Gong, Jian Xiao, Xiaokun Li, Yuanhong Li, Xinghua Gao, Xuegang Xu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Lgr6Genes & diseases · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Cytotechnology · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Editorial: Hair Follicle Stem Cell Regeneration in Aging.Frontiers in cell and developmental biology · 2021
    Article
  13. STAT3 Partly Inhibits Cell ProliferationFrontiers in genetics · 2021
    Article
  14. Review
  15. TWEAK regulates the functions of hair follicle stem cells via the Fn14-Wnt/β-catenin-CXCR4 signalling axis.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Lin GongDepartment of Dermatology, The First Hospital of China Medical University, Shenyang, China.
Jian XiaoSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Xiaokun LiSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Yuanhong LiDepartment of Dermatology, The First Hospital of China Medical University, Shenyang, China.
Xinghua GaoDepartment of Dermatology, The First Hospital of China Medical University, Shenyang, China.
Xuegang XuDepartment of Dermatology, The First Hospital of China Medical University, Shenyang, China.
China Medical University · CNWenzhou Medical University · CNFirst Affiliated Hospital of Dalian Medical University · CNFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWound-induced hair follicle neogenesis (WIHN) is a phenomenon of hair neogenesis that occurs at the center of a scar when the wound area is sufficiently large. Neogenic hair follicles are separated from the pre-existing follicles at the wound edge by a hairless circular region. This WIHN study provides a unique model for developing treatments for hair loss and deciphering the mechanisms underlying organogenesis in adult mammals.

methodsThe skin of a mouse was wounded by excising a 1.5 × 1.5 cm

resultsWe found that wounding induced IL-36α expression. Incorporation of recombinant murine IL-36α (mrIL-36α) into murine skin wounds resulted in a greater number of regenerated hair follicles (

conclusionIL-36α is upregulated in

Indexed as

hair follicleIL-36αIL-6/STAT3 pathwaystem cellwound epithelialization

Identifiers

PMID32984299
PMCPMC7493638
OpenAlexW3082458635

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.