ArticleJournal of family medicine and primary care2020
Evaluation of salivary flow rate, pH, and buffer capacities in end-stage renal disease patients versus control - A prospective comparative study.
Article in Journal of family medicine and primary care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 7 citations in OpenAlex.
- Effectiveness of thyme honey in the management of xerostomia in geriatric patients with end-stage renal disease: a randomized controlled clinical trial with a biochemical assessment.European journal of medical research · 2023Trial
- Influencing factors of oral frailty in Chinese maintenance hemodialysis patients: a Bayesian network analysis.Renal failure · 2026Article
- Xerogenic medications and clinical markers of salivary hypofunction.Clinical oral investigations · 2026Article
- Comparative ultrasonographic and clinical assessment of major salivary glands in patients with chronic kidney disease and healthy controls.Clinical oral investigations · 2026Article
- Oral health status and its predictors among hemodialysis patients in Saudi Arabia: a cross-sectional study.Scientific reports · 2026Article
- Salivary pH and buffering capacity among gastroesophageal reflux disease patients with dental erosion.Bioinformation · 2026Article
- Salivary Flow Rate in Patients with Kidney Failure on Hemodialysis-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Can unstimulated whole salivary flow objectively classify salivary gland secretory function in Sjögren's syndrome?Clinical rheumatology · 2024Article
- Ultrasensitive colorimetric detection of creatinineRSC advances · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSaliva plays a major role in preserving the integrity of oral tissues. Chronic renal failure patient undergoes many oral and salivary changes for which they require special oral health care. The patient undergoing hemodialysis session has altered salivary composition. Many changes occur during hemodialysis that severely affect the flow rate and the biochemical composition of saliva.
methodsA total of 50 patients of end-stage renal disease undergoing hemodialysis for renal insufficiency were selected based on inclusion and exclusion criteria set prior to the study. These patients were compared with the control group who had already undergone hemodialysis. A total of 30 patients were selected as a control group. In this study, unstimulated whole saliva was collected by the spitting method before and after the dialysis session. Salivary flow rate, pH, and buffering capacities were measured.
resultsHemodialysis had a significant effect on the salivary flow rate. The mean pH of unstimulated whole saliva showed no significant changes before and after dialysis. The concentrations of urea, creatinine, chloride, and potassium in the whole saliva changed markedly before and after a hemodialysis session, whereas no significant difference was seen in the concentration of sodium and calcium.
conclusionThrough this study, we came into a conclusion that hemodialysis had a significant effect on salivary secretion and the biochemical composition of saliva. We conclude that the observed changes in salivary concentrations and the flow rate are mainly due to an increased watery secretion from the salivary glands and also saliva can be used as a tool for monitoring hemodialysis.
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