Evidence map›Paper›PMID 32984088›Full record

ArticleResearch and reports in urology2020

Identification of Clinically Significant Prostate Cancer by Combined

Elena S Kotova, Yulia A Savochkina, Yuriy V Doludin, Alexander O Vasilyev, Elena A Prilepskay, Natalia V Potoldykova, Konstantin A Babalyan, Alexandra V Kanygina, Andrey O Morozov, Alexander V Govorov and 6 more

Open access · goldAbstract read
In one paragraph

Article in Research and reports in urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Elena S KotovaDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.ORCID 0000-0003-2342-524X
Yulia A SavochkinaLytech Ltd, Moscow, Russia.ORCID 0000-0001-5522-4579
Yuriy V DoludinSechenov First Moscow State Medical University, Moscow, Russia.ORCID 0000-0002-0554-9911
Alexander O VasilyevDepartment of Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.ORCID 0000-0001-5468-0011
Elena A PrilepskayDepartment of Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.ORCID 0000-0003-4599-6094
Natalia V PotoldykovaSechenov First Moscow State Medical University, Moscow, Russia.
Konstantin A BabalyanDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Alexandra V KanyginaDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Andrey O MorozovSechenov First Moscow State Medical University, Moscow, Russia.ORCID 0000-0001-6694-837X
Alexander V GovorovDepartment of Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
Dmitry V EnikeevSechenov First Moscow State Medical University, Moscow, Russia.ORCID 0000-0001-7169-2209
Elena S KostryukovaDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Elena N IlinaDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.ORCID 0000-0003-0130-5079
Vadim M GovorunDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.ORCID 0000-0003-0837-8764
Dmitry Y PushkarDepartment of Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
Elena I SharovaDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.ORCID 0000-0003-3208-9719
Federal Medical-Biological Agency · RUMoscow State University of Medicine and Dentistry · RUSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePreclinical evaluation of PATIENTS AND

methodsWe analyzed urine samples of patients with a total serum PSA ≥2 ng/mL: 31 men with prostate cancer scheduled for radical prostatectomy, 128 men scheduled for first diagnostic biopsy (prebiopsy cohort).

resultsThere was no significant difference between clinically significant and nonsignificant prostate cancer PCA3 scores. However, there was a significant difference in the AMACR score (patients scheduled for radical prostatectomy

conclusionThe AMACR score is a good predictor of clinically significant prostate cancer. Significant amounts of nonprostate RNA in urine may be a limitation for the AMACR score use. Evaluation of the AMACR score and classification models based on it for clinically significant prostate cancer detection with larger samples and a follow-up analysis is promising.

Indexed as

alpha-methylacyl-CoA racemaseearly diagnosisneoplasm gradingprostatic neoplasmsRNA

Identifiers

PMID32984088
PMCPMC7505712
OpenAlexW3085085585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.