Evidence map›Paper›PMID 32984074›Full record

ArticleFrontiers in cellular and infection microbiology2020

N-terminal Myristoylation Enhanced the Antimicrobial Activity of Antimicrobial Peptide PMAP-36PW.

Yongqing Liu, Shengnan Li, Tengfei Shen, Liangliang Chen, Jiangfei Zhou, Shuaibing Shi, Yang Wang, Zhanqin Zhao, Chengshui Liao, Chen Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  9. Antimicrobial Peptides: From Design to Clinical Application.Antibiotics (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yongqing LiuThe Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.
Shengnan LiDepartment of Animal Science, University of Manitoba, Winnipeg, MB, Canada.
Tengfei ShenThe Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.
Liangliang ChenThe Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.
Jiangfei ZhouThe Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.
Shuaibing ShiThe Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.
Yang WangHenan Provincial Open Laboratory of Key Disciplines in Environment and Animal Products Safety, Henan University of Science and Technology, Luoyang, China.
Zhanqin ZhaoThe Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.
Chengshui LiaoHenan Provincial Open Laboratory of Key Disciplines in Environment and Animal Products Safety, Henan University of Science and Technology, Luoyang, China.
Chen WangThe Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.
Henan University of Science and Technology · CNUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-resistant bacteria infections and drug residues have been increasing and causing antibiotic resistance and public health threats worldwide. Antimicrobial peptides (AMPs) are novel antimicrobial drugs with the potential to solve these problems. Here, a peptide based on our previously studied peptide PMAP-36PW was designed via N-terminal myristoylation and referred to as Myr-36PW. The fatty acid modification provided the as-prepared peptide with good stability and higher antimicrobial activity compared with PMAP-36PW

Indexed as

Anti-Infective AgentsAntimicrobial Cationic PeptidesAnimalsAnti-Bacterial AgentsMiceMicrobial Sensitivity TestsPore Forming Cytotoxic ProteinsPseudomonas aeruginosaAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesPore Forming Cytotoxic Proteinsantibacterial activityantibacterial peptide Myr-36PWantibacterial peptide PMAP-36PWanti-biofilmmechanismmyristoylationstabilitytherapeutic efficacy

Identifiers

PMID32984074
PMCPMC7481357
OpenAlexW3080413129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.