Evidence map›Paper›PMID 32984065›Full record

ArticleFrontiers in cellular and infection microbiology2020

Differential CD4 T Regulatory Cell Phenotype Induced by Andes Hantavirus Glycoprotein.

Farides Saavedra, Jose L Garrido, Francisco Fuentes-Villalobos, Mario Calvo, Raúl Riquelme, María Luisa Rioseco, Carolina Chahín, Leonila Ferreira, Raymond Alvarez, Estefania Nova-Lamperti and 1 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Farides SaavedraDepartment of Microbiology, Faculty of Biological Science, Biotechnology Center, Universidad de Concepción, Concepción, Chile.
Jose L GarridoDepartment of Microbiology, Faculty of Biological Science, Biotechnology Center, Universidad de Concepción, Concepción, Chile.
Francisco Fuentes-VillalobosDepartment of Microbiology, Faculty of Biological Science, Biotechnology Center, Universidad de Concepción, Concepción, Chile.
Mario CalvoInstitute of Medicine, Universidad Austral de Chile, Valdivia, Chile.
Raúl RiquelmeHospital Puerto Montt Dr. Eduardo Schoütz Schroeder, Puerto Montt, Chile.
María Luisa RiosecoHospital Puerto Montt Dr. Eduardo Schoütz Schroeder, Puerto Montt, Chile.
Carolina ChahínHospital Regional Temuco Dr. Hernán Henríquez Aravena, Temuco, Chile.
Leonila FerreiraHospital Clínico Regional Guillermo Grant Benavente, Concepción, Chile.
Raymond AlvarezIchor Biologics LLC, New York, NY, United States.
Estefania Nova-LampertiDepartment of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepción, Concepción, Chile.
Maria Ines BarriaDepartment of Microbiology, Faculty of Biological Science, Biotechnology Center, Universidad de Concepción, Concepción, Chile.

Funding

Development of broadly neutralizing antibodies to treat hantavirus infectionsR43AI138740 · NIAID · ICHOR BIOLOGICS, LLC · PI ALVAREZ, RAYMOND · 2019 to 2020
$355k
NIAID NIH HHS R43 AI138740
6 · The paper itself

Abstract

Hantavirus cardiopulmonary syndrome (HCPS) caused by Andes orthohantavirus (ANDV) in South America is a public health threat due to the significant rate of mortality and the lack of a specific treatment. Interestingly, the virus does not produce cytopathic effect, thereby the strong antiviral immune response is suspected to contribute to pathogenesis, hence is important to understand the balance between protective and harmfully immunity. CD4

Indexed as

Hantavirus InfectionsOrthohantavirusGlycoproteinsHumansPhenotypeT-Lymphocytes, RegulatoryGlycoproteinsANDV-GPCD4 TregCXCR3HCPSTh1/Th2Th-like TregVLPs

Identifiers

PMID32984065
PMCPMC7477076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.