Evidence map›Paper›PMID 32983907›Full record

ReviewInternet interventions2020

Estimating causal effects of internet interventions in the context of nonadherence.

Hugo Hesser

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internet interventions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Hugo HesserSchool of Law, Psychology and Social Work, Center for Health and Medical Psychology, Örebro University, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A substantial proportion of participants who are offered internet-based psychological treatments in randomized trials do not adhere and may therefore not receive treatment. Despite the availability of justified statistical methods for causal inference in such situations, researchers often rely on analytical strategies that either ignore adherence altogether or fail to provide causal estimands. The objective of this paper is to provide a gentle nontechnical introduction to complier average causal effect (CACE) analysis, which, under clear assumptions, can provide a causal estimate of the effect of treatment for a subsample of compliers. The article begins with a brief review of the potential outcome model for causal inference. After clarifying assumptions and model specifications for CACE in the latent variable framework, data from a previously published trial of an internet-based psychological treatment for irritable bowel syndrome are used to demonstrate CACE-analysis. Several model extensions are then briefly reviewed. The paper offers practical recommendations on how to analyze randomized trials of internet interventions in the context of nonadherence. It is argued that CACE-analysis, whenever it is considered appropriate, should be carried out as a complement to the standard intention-to-treat analysis and that the format of internet-based treatments is particularly well suited to such an analytical approach.

Indexed as

AdherenceComplier average causal effectMixture modelingPsychological treatmentRandomized trialStructural equation modeling

Identifiers

PMID32983907
PMCPMC7495102

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.