Evidence map›Paper›PMID 32983902›Full record

ArticleToxicology reports2020

The in vitro assessment of a novel vaping technology.

D Breheny, D Thorne, A Baxter, S Bozhilova, T Jaunky, S Santopietro, M Taylor, A Terry, M Gaça

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Key Challenges forAlternatives to laboratory animals : ATLA · 2024
    Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

D BrehenyBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
D ThorneBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
A BaxterBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
S BozhilovaBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
T JaunkyBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
S SantopietroBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
M TaylorBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
A TerryBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
M GaçaBritish American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
British American Tobacco (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have developed a novel vaping product (NVP) IS1.0(TT), which utilises a stainless-steel mesh to transfer and vaporise the e-liquid, mitigating some of the potential sources of toxicants that can be generated using the more traditional 'wick and coil' approach. The emissions from IS1.0(TT) have previously been found to have lower levels of toxicants overall when directly compared with a commercial wick and coil e-cig. This current study assessed the toxicological responses to aerosols from this NVP. Responses induced by IS1.0(TT)were compared to those from a 3R4F reference cigarette, using

Indexed as

ACM, aerosol collected massAerosolALI, air-liquid interfaceANOVA, analysis of varianceAqE, aerosol aqueous extractAqE, aqueous aerosol extractsARE, antioxidant response elementCigaretteCRM81, CORESTA recommended method number 81DCF, 2′,7′ dichlorodihydrofluoresceinDMSO, dimethyl sulfoxideDSB, double-strand breakElectronic cigaretteFDA, US Food and Drug AdministrationGEF, global evaluation factorGSH, glutathione (reduced form)HCI, Health Canada IntenseHUVEC, human umbilical vein endothelial cellIn vitroISO, International Organisation for StandardisationIVMn, in vitro micronucleusMF, mutant frequencyMLA, mouse lymphoma assayNASEM, US National Academy of Sciences, Engineering and MedicineNHBE, normal human bronchial epithelialNRU, neutral red uptakeNVP, new vapour productRWD, relative wound densityS9, post-mitochondrial supernatantTobReg, WHO Study Group on Tobacco Product RegulationTPA, 12-O-tetradecanoylphorbol-13-acetateTPM, total particulate matterWA, whole aerosol

Identifiers

PMID32983902
PMCPMC7494588
OpenAlexW3080410272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.