ArticlePeerJ2020
Integrated analysis of the transcriptome-wide m6A methylome in preeclampsia and healthy control placentas.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Review
- METTL14 promotes trophoblast dysfunction by elevating SZRD1 expression in an m6A-dependent manner.Human cell · 2026Article
- PPP1R1C: a specific placental mRNA biomarker for distinguishing preeclampsia from healthy pregnancies.BMC pregnancy and childbirth · 2026Article
- Decoding m6A: a new frontier in maternal-foetal immunology.Frontiers in immunology · 2026Review
- A novel m7G RNA methylation-related signature associated with MAPK signaling pathways in acute ischemic stroke.PloS one · 2026Article
- Analysis of immune-related biomarkers in amniotic fluid embolism by sequencing data and bioinformatics.BMC pregnancy and childbirth · 2025Article
- Extracellular Vesicles Alter Trophoblast Function in Pregnancies Complicated by COVID-19.Journal of extracellular vesicles · 2025Article
- Regulatory role and molecular mechanism of METTL14 in vascular endothelial cell injury in preeclampsia.Biomolecules & biomedicine · 2025Article
- Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus.iScience · 2024Article
- Article
- Preeclampsia in mice carrying fetuses with APOL1 risk variants.bioRxiv : the preprint server for biology · 2024Article
- Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia.European journal of medical research · 2023Article
- Excessive Gestational Weight Gain Alters DNA Methylation and Influences Foetal and Neonatal Body Composition.Epigenomes · 2023Article
- RNA NCell communication and signaling : CCS · 2023Review
- Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.Molecular medicine (Cambridge, Mass.) · 2023Article
- Identification of Comorbidities, Genomic Associations, and Molecular Mechanisms for COVID-19 Using Bioinformatics Approaches.BioMed research international · 2023Article
- Gene model-related m6A expression levels predict the risk of preeclampsia.BMC medical genomics · 2022Article
- Pregnancy exposure to phthalates and DNA methylation in male placenta - An epigenome-wide association study.Environment international · 2022Article
- METTL3-Mediated mFrontiers in cell and developmental biology · 2022Article
- Fear Stress During Pregnancy Affects Placental m6A-Modifying Enzyme Expression and Epigenetic Modification Levels.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNA and potential regulatory functions of m6A have been shown by mapping the RNA m6A modification landscape. m6A modification in active gene regulation manifests itself as altered methylation profiles. The number of reports regarding to the profiling of m6A modification and its potential role in the placenta of preeclampsia (PE) is small. In this work, placental samples were collected from PE and control patients. Expression of m6A-related genes was investigated using quantitative real-time PCR. MeRIP-seq and RNA-seq were performed to detect m6A methylation and mRNA expression profiles. Gene ontology (GO) functional and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses were also conducted to explore the modified genes and their clinical significance. Our findings show that METTL3 and METTL14 were up-regulated in PE. In total, 685 m6A peaks were differentially expressed as determined by MeRIP-seq. Altered peaks of m6A-modified transcripts were primarily associated with nitrogen compound metabolic process, positive regulation of vascular-associated smooth muscle cell migration, and endoplasmic reticulum organisation. The m6A hyper-methylated genes of Wnt/
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.