Evidence map›Paper›PMID 32983613›Full record

ArticleNeurology. Clinical practice2020

Association between recent cannabinoid use and acute ischemic stroke.

Carmela V San Luis, Christa O'Hana S Nobleza, Shashank Shekhar, Rebecca Sugg, Darren J Villareal, Tapan Mehta, Shreyas Gangadhara

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Does illicit drug use increase stroke risk? A systematic review, meta-analyses, and Mendelian randomization analysis.International journal of stroke : official journal of the International Stroke Society · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Carmela V San LuisDepartment of Neurology (CVSL), University of Mississippi Medical Center; Division of Neurosciences Critical Care (COHSN), Department of Neurology, University of Mississippi Medical Center, Jackson; Division of Cerebrovascular Diseases (SS, RS, SG), Department of Neurology, University of Mississippi Medical Center, Jackson; Information Technology (DJV), CAP College Foundation, Inc., The Digitalized Distance Education, Makati City, Philippines; and Department of Neurology (TM), Neurosurgery and Radiology, University of Minnesota, Minneapolis.
Christa O'Hana S NoblezaDepartment of Neurology (CVSL), University of Mississippi Medical Center; Division of Neurosciences Critical Care (COHSN), Department of Neurology, University of Mississippi Medical Center, Jackson; Division of Cerebrovascular Diseases (SS, RS, SG), Department of Neurology, University of Mississippi Medical Center, Jackson; Information Technology (DJV), CAP College Foundation, Inc., The Digitalized Distance Education, Makati City, Philippines; and Department of Neurology (TM), Neurosurgery and Radiology, University of Minnesota, Minneapolis.ORCID 0000-0001-7223-2650
Shashank ShekharDepartment of Neurology (CVSL), University of Mississippi Medical Center; Division of Neurosciences Critical Care (COHSN), Department of Neurology, University of Mississippi Medical Center, Jackson; Division of Cerebrovascular Diseases (SS, RS, SG), Department of Neurology, University of Mississippi Medical Center, Jackson; Information Technology (DJV), CAP College Foundation, Inc., The Digitalized Distance Education, Makati City, Philippines; and Department of Neurology (TM), Neurosurgery and Radiology, University of Minnesota, Minneapolis.ORCID 0000-0002-5124-7981
Rebecca SuggDepartment of Neurology (CVSL), University of Mississippi Medical Center; Division of Neurosciences Critical Care (COHSN), Department of Neurology, University of Mississippi Medical Center, Jackson; Division of Cerebrovascular Diseases (SS, RS, SG), Department of Neurology, University of Mississippi Medical Center, Jackson; Information Technology (DJV), CAP College Foundation, Inc., The Digitalized Distance Education, Makati City, Philippines; and Department of Neurology (TM), Neurosurgery and Radiology, University of Minnesota, Minneapolis.
Darren J VillarealDepartment of Neurology (CVSL), University of Mississippi Medical Center; Division of Neurosciences Critical Care (COHSN), Department of Neurology, University of Mississippi Medical Center, Jackson; Division of Cerebrovascular Diseases (SS, RS, SG), Department of Neurology, University of Mississippi Medical Center, Jackson; Information Technology (DJV), CAP College Foundation, Inc., The Digitalized Distance Education, Makati City, Philippines; and Department of Neurology (TM), Neurosurgery and Radiology, University of Minnesota, Minneapolis.
Tapan MehtaDepartment of Neurology (CVSL), University of Mississippi Medical Center; Division of Neurosciences Critical Care (COHSN), Department of Neurology, University of Mississippi Medical Center, Jackson; Division of Cerebrovascular Diseases (SS, RS, SG), Department of Neurology, University of Mississippi Medical Center, Jackson; Information Technology (DJV), CAP College Foundation, Inc., The Digitalized Distance Education, Makati City, Philippines; and Department of Neurology (TM), Neurosurgery and Radiology, University of Minnesota, Minneapolis.ORCID 0000-0003-0199-3967
Shreyas GangadharaDepartment of Neurology (CVSL), University of Mississippi Medical Center; Division of Neurosciences Critical Care (COHSN), Department of Neurology, University of Mississippi Medical Center, Jackson; Division of Cerebrovascular Diseases (SS, RS, SG), Department of Neurology, University of Mississippi Medical Center, Jackson; Information Technology (DJV), CAP College Foundation, Inc., The Digitalized Distance Education, Makati City, Philippines; and Department of Neurology (TM), Neurosurgery and Radiology, University of Minnesota, Minneapolis.
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies that have analyzed the association between cannabis use and acute ischemic stroke (AIS) have provided conflicting results. In this study, we aim to determine the association of recent cannabis use detected through urine drug screen (UDS) among patients admitted with AIS.

methodsA retrospective observational study was performed using the medical records database. All patients aged 18 years and older admitted from January 1, 2015, to December 31, 2017, who underwent urine toxicology testing on admission were included in the analysis. Multivariate logistic regression analysis was performed to analyze independent association between recent cannabis use and AIS.

resultsA total of 9,350 patients were determined to have undergone UDS during admission, and 18% (1,643) of this had a positive urine cannabis test. Unadjusted risk ratio showed a 50% decrease in risk of AIS among cannabis users (risk ratio = 0.505, 95% confidence interval [CI] 0.425-0.600). The effect was lost after adjusting for age, race, ethnicity, sickle cell disease, dyslipidemia, hypertension, obesity, diabetes mellitus, cigarette smoking, atrial fibrillation, and other cardiac conditions (odds ratio 1.038, 95% CI 0.773-1.394).

conclusionThis is one of the few studies analyzing the association of recent cannabis use and AIS using admission urine toxicology test independent of polysubstance use. Although our study has limitations, we did not find an independent association between recent cannabis use and the incidence of AIS. Further studies using urine toxicology tests with larger sample size and including dosage of cannabis exposure should be conducted.

Identifiers

PMID32983613
PMCPMC7508332
OpenAlexW3033644589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.