ArticleNeurology. Clinical practice2020
Deep brain stimulation for orthostatic tremor: A single-center case series.
Article in Neurology. Clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Orthostatic tremor and its subtypes: a single centre cohort of 74 patients.Journal of neurology · 2026Article
- Multidimensional Phenotyping of Orthostatic Tremor and Orthostatic Myoclonus: Baseline Findings from a Longitudinal Clinical Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Effect of Orthostatic Tremor on Quality of Life - a Cohort Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Deep Brain Stimulation for Orthostatic Tremor: An Observational Study.Movement disorders clinical practice · 2024Observational
- TMS of the left primary motor cortex improves tremor intensity and postural control in primary orthostatic tremor.Journal of neurology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOrthostatic tremor (OT) is a high-frequency weight-bearing tremor of the legs and trunk associated with progressive disability and is often refractory to medications. Case reports suggest that thalamic deep brain stimulation (DBS) is effective. We report 5 female patients with medication-refractory OT who underwent bilateral thalamic DBS at the Mayo Clinic and assess factors associated with a successful DBS outcome.
methodsDemographic, clinical, electrophysiology, and DBS data were abstracted. Outcomes were change in tremor-onset latency, standing time, standing ADLs, and patient and clinician global impression of change (PGIC; CGIC).
resultsAll 5 patients had improved standing time (72 vs 408 seconds,
conclusionsBilateral thalamic DBS improved OT symptoms with benefit lasting up to 6 years. A modest increase in standing time of several minutes was associated with meaningful improvement in standing ADLs. Microlesional effect and bilateral stimulation are likely favorable features, while baseline standing time of several minutes may be unfavorable. These findings may inform clinician and patient counseling and require confirmation in larger studies.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.