Evidence map›Paper›PMID 32983346›Full record

ArticleThe Neurohospitalist2020

Stroke Risk Following Takotsubo Cardiomyopathy.

Nicholas A Morris, Monica Lin Chen, Oluwayemisi L Adejumo, Santosh B Murthy, Hooman Kamel, Alexander E Merkler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Neurohospitalist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Incidence of ischemic stroke in Takotsubo cardiomyopathy patients: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicholas A MorrisProgram in Trauma, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-1270-9805
Monica Lin ChenClinical and Translational Neuroscience Unit, Division of Cardiology, Department of Neurology, Feil Family Brain and Mind Research Institute, and Weill Cornell Medicine, New York, NY, USA.
Oluwayemisi L AdejumoClinical and Translational Neuroscience Unit, Division of Cardiology, Department of Neurology, Feil Family Brain and Mind Research Institute, and Weill Cornell Medicine, New York, NY, USA.
Santosh B MurthyClinical and Translational Neuroscience Unit, Division of Cardiology, Department of Neurology, Feil Family Brain and Mind Research Institute, and Weill Cornell Medicine, New York, NY, USA.
Hooman KamelClinical and Translational Neuroscience Unit, Division of Cardiology, Department of Neurology, Feil Family Brain and Mind Research Institute, and Weill Cornell Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0002-5745-0307
Alexander E MerklerClinical and Translational Neuroscience Unit, Division of Cardiology, Department of Neurology, Feil Family Brain and Mind Research Institute, and Weill Cornell Medicine, New York, NY, USA.
Cornell University · USUniversity of Maryland, Baltimore · US

Funding

Left Atrial abNormality, ThromboEmbolism, and Race: Novel risk factors for stroke (LANTERN)R01NS097443 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KAMEL, HOOMAN · 2016 to 2019
$1.5M
Intracerebral Hemorrhage and Increased Risk of Arterial ThromboembolismK23NS105948 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MURTHY, SANTOSH BHASKAR · 2018 to 2022
$972k
NINDS NIH HHS K23 NS105948NINDS NIH HHS R01 NS097443
6 · The paper itself

Abstract

background and purposeTakotsubo cardiomyopathy, also known as stress cardiomyopathy, is an increasingly recognized cause of left ventricular dysfunction. Previously considered a benign disease, Takotsubo cardiomyopathy may be a risk factor of ischemic stroke based on recent small, single-center case series. The strength and temporal profile of this association remains uncertain.

methodsWe performed a cohort-crossover study using administrative claims data on all emergency department visits and acute care hospitalizations from 2005 to 2015 in California, New York, and Florida. We identified patients with Takotsubo cardiomyopathy, excluding those with a prior or concomitant stroke diagnosis. We compared the risk of ischemic stroke in the first year after Takotsubo cardiomyopathy to the risk of ischemic stroke in the second year after Takotsubo cardiomyopathy. Takotsubo cardiomyopathy and ischemic stroke were ascertained using previously validated

resultsAmong 5283 patients with Takotsubo cardiomyopathy (mean age, 67 years; 92% female), we identified 49 ischemic strokes during the first year after Takotsubo cardiomyopathy versus 19 ischemic strokes during the second year after. The risk of stroke was significantly higher in the year after Takotsubo cardiomyopathy (absolute increase, 0.6%; 95% CI: 0.2-0.9; OR: 2.6; 95% CI: 1.5-4.6) as compared to the control period.

conclusionWe found a heightened risk of ischemic stroke in the year after a diagnosis of Takotsubo cardiomyopathy, although the absolute risk increase was small.

Indexed as

cardiomyopathycerebrovascular disordersepidemiologystroketechniques

Identifiers

PMID32983346
PMCPMC7495697
OpenAlexW3035029522

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.