ArticleThe Journal of clinical investigation1987
Acute tropical pulmonary eosinophilia. Characterization of the lower respiratory tract inflammation and its response to therapy.
Article in The Journal of clinical investigation, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 78 citations in OpenAlex.
- Pathogenic type-2 immunity beyond allergy: the role of Th2 cell heterogeneity in helminth infections.Infection and immunity · 2026Review
- Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner.PLoS pathogens · 2024Article
- Pulmonary Infiltrates With Hypereosinophilia.The journal of allergy and clinical immunology. In practice · 2024Article
- Eosinophils and helminth infection: protective or pathogenic?Seminars in immunopathology · 2021Review
- Host Immunity and Inflammation to Pulmonary Helminth Infections.Frontiers in immunology · 2020Review
- Tropical pulmonary eosinophilia--a review.The Indian journal of medical research · 2013Review
- Eosinophilic pneumonias.Clinical microbiology reviews · 2012Review
- Role of oxidants in interstitial lung diseases: pneumoconioses, constrictive bronchiolitis, and chronic tropical pulmonary eosinophilia.Mediators of inflammation · 2011Review
- Pneumonia and other respiratory infections.Pediatric clinics of North America · 2009Review
- Loffler's syndrome associated with Clonorchis sinensis infestation.The Korean journal of internal medicine · 2003Article
- Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia.Infection and immunity · 2003Article
- Reciprocal immunomodulatory effects of gamma interferon and interleukin-4 on filaria-induced airway hyperresponsiveness.Infection and immunity · 2001Article
- An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness.Infection and immunity · 1998Article
- A major allergen of lymphatic filarial nematodes is a parasite homolog of the gamma-glutamyl transpeptidase.Molecular medicine (Cambridge, Mass.) · 1996Article
- A morphometric study of normodense and hypodense human eosinophils that are derived in vivo and in vitro.The American journal of pathology · 1990Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although acute tropical pulmonary eosinophilia (TPE) is well recognized as a manifestation of filarial infection, the processes that mediate the abnormalities of the lung in TPE are unknown. To evaluate the hypothesis that the derangements of the lower respiratory tract in this disorder are mediated by inflammatory cells in the local milieu, we utilized bronchoalveolar lavage to evaluate affected individuals before and after therapy. Inflammatory cells recovered from the lower respiratory tract of individuals with acute, untreated TPE (n = 8) revealed a striking eosinophilic alveolitis, with marked elevations in both the proportion of eosinophils (TPE 54 +/- 5%; normal 2 +/- 5%; P less than 0.001) and the concentration of eosinophils in the recovered epithelial lining fluid (ELF) (TPE 63 +/- 20 X 10(3)/microliter; normal 0.3 +/- 0.1 X 10(3)/microliter; P less than 0.01). Importantly, when individuals (n = 5) with acute TPE were treated with diethylcarbamazine (DEC), there was a marked decrease of the lung eosinophils and concomitant increase in lung function. These observations are consistent with the concept that at least some of the abnormalities found in the lung in acute TPE are mediated by an eosinophil-dominated inflammatory process in the lower respiratory tract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.