Evidence map›Paper›PMID 32983143›Full record

ArticleFrontiers in immunology2020

Circulating and Salivary Antibodies to

Hassan Alkharaan, Liyan Lu, Giorgio Gabarrini, Asif Halimi, Zeeshan Ateeb, Michał J Sobkowiak, Haleh Davanian, Carlos Fernández Moro, Leif Jansson, Marco Del Chiaro and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Review
  3. Metaplasia Enables Stomach Colonization bybioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. MedComm · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Application ofWorld journal of gastrointestinal oncology · 2024
    Article
  13. Review
  14. Review
  15. IgYs: on her majesty's secret service.Frontiers in immunology · 2023
    Review
  16. Review
  17. Review
  18. Science signaling · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hassan AlkharaanDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Liyan LuDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Giorgio GabarriniDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Asif HalimiPancreatic Surgery Unit, Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Huddinge, Sweden.
Zeeshan AteebPancreatic Surgery Unit, Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Huddinge, Sweden.
Michał J SobkowiakDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Haleh DavanianDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Carlos Fernández MoroDivision of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
Leif JanssonClinic of Endodontics and Periodontology, Eastman Institute Stockholm, Stockholm, Sweden.
Marco Del ChiaroDivision of Surgical Oncology, Department of Surgery, University of Colorado, Aurora, CO, United States.
Volkan ÖzenciDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
Margaret Sällberg ChenDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Intraductal papillary mucinous neoplasms (IPMNs) are cystic precursor lesions to pancreatic cancer. The presence of oral microbes in pancreatic tissue or cyst fluid has been associated with high-grade dysplasia (HGD) and cancer. The present study aims at investigating if humoral immunity to pancreas-associated oral microbes reflects IPMN severity. Design: Paired plasma ( Results: The patient group with high-risk cystic tumors (HGD and/or associated invasive cancer) shows ample circulating IgG reactivity to Conclusion: Our findings indicate that humoral reactivity against pancreas-associated oral microbes may reflect IPMN severity. These findings are beneficial for biomarker development.

Indexed as

AdultAgedAntibodies, BacterialBloodFemaleFusobacterium InfectionsFusobacterium nucleatumHumansMaleMiddle AgedNeoplasm StagingPancreatic Intraductal NeoplasmsPancreatic NeoplasmsRiskSalivaAntibodies, Bacterialhumoral responseIPMNoral commensalspancreatic cancerpancreatic cyst neoplasm

Identifiers

PMID32983143
PMCPMC7484485

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.