Evidence map›Paper›PMID 32983121›Full record

ArticleFrontiers in immunology2020

Cervico-Vaginal Inflammatory Cytokine and Chemokine Responses to Two Different SIV Immunogens.

Nikki P L Toledo, Hongzhao Li, Robert W Omange, Tamara G Dacoba, Jose Crecente-Campo, Dane Schalk, Mohammad A Kashem, Eva Rakasz, Nancy Schultz-Darken, Qingsheng Li and 4 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Nikki P L ToledoDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Hongzhao LiDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Robert W OmangeDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Tamara G DacobaCenter for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Jose Crecente-CampoCenter for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Dane SchalkScientific Protocol Implementation Unit, Wisconsin National Primate Research Center, Madison, WI, United States.
Mohammad A KashemDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Eva RakaszScientific Protocol Implementation Unit, Wisconsin National Primate Research Center, Madison, WI, United States.
Nancy Schultz-DarkenScientific Protocol Implementation Unit, Wisconsin National Primate Research Center, Madison, WI, United States.
Qingsheng LiNebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States.
James B WhitneyCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Maria J AlonsoCenter for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Francis A PlummerDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Ma LuoDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
University of Manitoba · CACenter for Research in Molecular Medicine and Chronic Diseases · ESBeth Israel Deaconess Medical Center · USPublic Health Agency of Canada · CAUniversidade de Santiago de Compostela · ESUniversity of Nebraska–Lincoln · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
A Novel HIV-1 Vaccine Targeting the 12 protease Cleavage SitesR01AI111805 · NIAID · UNIVERSITY OF MANITOBA · PI LUO, MA, PLUMMER, FRANK A · 2014 to 2017
$2.8M
NIAID NIH HHS R01 AI111805NIH HHS P51 OD011106
6 · The paper itself

Abstract

Studies have shown that vaccine vectors and route of immunization can differentially activate different arms of the immune system. However, the effects of different HIV vaccine immunogens on mucosal inflammation have not yet been studied. Because mucosal sites are the primary route of HIV infection, we evaluated the cervico-vaginal inflammatory cytokine and chemokine levels of Mauritian cynomolgus macaques following immunization and boost using two different SIV vaccine immunogens. The PCS vaccine delivers 12 20-amino acid peptides overlapping the 12 protease cleavage sites, and the Gag/Env vaccine delivers the full Gag and full Env proteins of simian immunodeficiency virus. We showed that the PCS vaccine prime and boosts induced short-lived, lower level increases of a few pro-inflammatory/chemotactic cytokines. In the PCS-vaccine group only the levels of MCP-1 were significantly increased above the baseline (

Indexed as

AnimalsCervix UteriCytokinesFemaleGene Products, envGene Products, gagInflammation MediatorsMacaca fascicularisMucous MembraneSAIDS VaccinesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusTime FactorsVaccinationVaccines, SyntheticVaginaCytokinesGene Products, envGene Products, gagInflammation MediatorsSAIDS VaccinesVaccines, SyntheticHIVmucosal inflammationnon-human primatespro-inflammatory cytokine/chemokine(s)SIVvaccine

Identifiers

PMID32983121
PMCPMC7477078
OpenAlexW3080906966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.