Evidence map›Paper›PMID 32983106›Full record

ArticleFrontiers in immunology2020

Analysis of Co-inhibitory Receptor Expression in COVID-19 Infection Compared to Acute

Marissa Herrmann, Sophia Schulte, Nils H Wildner, Melanie Wittner, Thomas Theo Brehm, Michael Ramharter, Robin Woost, Ansgar W Lohse, Thomas Jacobs, Julian Schulze Zur Wiesch

Abstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. The LEF1-LAG3 axis regulates CD4Parasites & vectors · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Cellular Immunological Memory T Cells andDiagnostics (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marissa HerrmannInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sophia SchulteInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nils H WildnerInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Melanie WittnerInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thomas Theo BrehmInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Michael RamharterInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Robin WoostInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ansgar W LohseInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thomas JacobsProtozoa Immunology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Julian Schulze Zur WieschInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

Deutsche Forschungsgemeinschaft
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) which is caused by the novel SARS-CoV-2 virus is a severe flu-like illness which is associated with hyperinflammation and immune dysfunction. The virus induces a strong T and B cell response but little is known about the immune pathology of this viral infection. Acute

Indexed as

Acute DiseaseAdultAgedAntigens, CDBetacoronavirusCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCohort StudiesCoronavirus InfectionsCOVID-19FemaleHepatitis A Virus Cellular Receptor 2HumansLymphocyte ActivationLymphocyte Activation Gene 3 ProteinAntigens, CDHepatitis A Virus Cellular Receptor 2Lymphocyte Activation Gene 3 ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellCOVID-19LAG-3malariaPD-1Plasmodium falciparumSARS-CoV-2T cellsTIM-3

Identifiers

PMID32983106
PMCPMC7479337

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.