Evidence map›Paper›PMID 32983071›Full record

ArticleFrontiers in microbiology2020

Antimicrobial Synergism Toward

Anna C Zemke, Cody J Madison, Naomi Kasturiarachi, Linda L Pearce, James Peterson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Bacterial respiratory inhibition triggers dispersal ofApplied and environmental microbiology · 2023
    Article
  7. Review
  8. Review
  9. Review
  10. Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna C ZemkeDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Cody J MadisonEnvironmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.
Naomi KasturiarachiDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Linda L PearceEnvironmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.
James PetersonEnvironmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.
University of Pittsburgh · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
Nebulized Nitrite as a Novel Antimicrobial Therapy in Cystic FibrosisK23HL131930 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZEMKE, ANNA CHRISTINE · 2016 to 2020
$865k
NHLBI NIH HHS K23 HL131930NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

The ubiquitous involvement of key iron-containing metalloenzymes in metabolism is reflected in the dependence of virtually all bacteria on iron for growth and, thereby, potentially provides multiple biomolecular targets for antimicrobial killing. We hypothesized that nitrosative stress, which induces damage to iron metalloproteins, would sensitize bacteria to the ferric iron mimic gallium(III) (Ga

Indexed as

biofilmGa3+gallium(III)nitric oxidenitritePseudomonas aeruginosa

Identifiers

PMID32983071
PMCPMC7487421
OpenAlexW3082483292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.