Evidence map›Paper›PMID 32982978›Full record

ArticleFrontiers in endocrinology2020

Urinary Exosomal MiRNA-4534 as a Novel Diagnostic Biomarker for Diabetic Kidney Disease.

Yanyan Zhao, Ao Shen, Feng Guo, Yi Song, Na Jing, Xiaoxu Ding, Mengxing Pan, Haohao Zhang, Jiao Wang, Lina Wu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 6 syntheses or guidelines pooled it, 70 citations in OpenAlex.

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  12. Urinary biomarkers of diabetic kidney disease.World journal of diabetes · 2026
    Review
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  14. Research progress on the regulation of miRNAs in diabetic kidney disease and osteoporosis.International journal of clinical and experimental pathology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yanyan ZhaoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ao ShenThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Feng GuoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yi SongThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Na JingThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoxu DingThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Mengxing PanThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Haohao ZhangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jiao WangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lina WuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaojun MaThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liang FengSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Guijun QinThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CNChina Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary exosomal miRNAs can reflect the physiological and possibly pathophysiological state of cells lining the kidney and participate in the regulation of transcription and translation of proteins, which are playing an important role in the pathogenesis of diabetic kidney disease. In the present study, urine was collected from DM and DKD patients with a duration more than 10 years and urinary exosomal miRNA profiling was conducted in urinary exosomes obtained from three patients with type 2 diabetes (DM) and three patients with type 2 diabetic kidney disease (DKD) using Exiqon's microRNA arrays. In total, the expression of 14 miRNAs (miR-4491, miR-2117, miR-4507, miR-5088-5P, miR-1587, miR-219a-3p, miR-5091, miR-498, miR-4687-3p, miR-516b-5p, miR-4534, miR-1275, miR-5007-3p, and miR-4516) was up-regulated (>2-fold) in DKD patients compared to healthy controls and DM patients. We used qRT-PCR based analysis of these 14 miRNAs in urinary exosomes from 14 DKD to 14 DM patients in confirmation cohort, among which seven miRNAs were consistent with the microarray results. The expressions of miR-4534 and miR-516b-5p correlated with trace proteinuria levels in the confirmation cohort. In conclusion, it has been confirmed that the expression of urinary exosomal miRNA in patients with type 2 diabetes DKD has changed. Mir-4534 might affect the FoxO signaling pathway by targeting BNIP3, and is expected to become a new biomarker for the progression of type 2 DKD disease, which will provide further research on the pathogenesis of DKD.

Indexed as

AgedBiomarkersDiabetic NephropathiesExosomesGene Expression ProfilingHumansKidneyMaleMicroRNAsMiddle AgedBiomarkersMicroRNAsbiomarkerdiabetic kidney diseasediagnostic valueMiRNAurinary exosomes

Identifiers

PMID32982978
PMCPMC7484971
OpenAlexW3081546809

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.