Evidence map›Paper›PMID 32982961›Full record

ArticleFrontiers in endocrinology2020

CRLF1-MYH9 Interaction Regulates Proliferation and Metastasis of Papillary Thyroid Carcinoma Through the ERK/ETV4 Axis.

Shi-Tong Yu, Bai-Hui Sun, Jun-Na Ge, Jiao-Long Shi, Man-Sheng Zhu, Zhi-Gang Wei, Ting-Ting Li, Zhi-Cheng Zhang, Wei-Sheng Chen, Shang-Tong Lei

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shi-Tong YuDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Bai-Hui SunDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jun-Na GeDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jiao-Long ShiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Man-Sheng ZhuDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhi-Gang WeiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ting-Ting LiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhi-Cheng ZhangDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wei-Sheng ChenDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Shang-Tong LeiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nanfang Hospital · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our previous study, we have shown that CRLF1 can promote proliferation and metastasis of papillary thyroid carcinoma (PTC); however, the mechanism is unclear. Herein, we investigated whether the interaction of CRLF1 and MYH9 regulates proliferation and metastasis of PTC cells via the ERK/ETV4 axis. Immunohistochemistry (IHC), qPCR, and Western blotting assays were performed on PTC cells and normal thyroid cells to profile specific target genes.

Indexed as

Cell ProliferationMAP Kinase Signaling SystemAdolescentAdultAgedAnimalsApoptosisBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudeMiddle AgedBiomarkers, Tumorcytokine-like factor-1ETV4 protein, humanMYH9 protein, humanMyosin Heavy ChainsProto-Oncogene Proteins c-etsReceptors, CytokineCRLF1EtV4MYH9papillary thyroid carcinomatumor progression

Identifiers

PMID32982961
PMCPMC7477767
OpenAlexW3081371633

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.