ArticleFrontiers in psychiatry2020
The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Microbial dysbiosis as a diagnostic marker in psychiatric disorders: a systematic review of gut-brain axis disruptions.Frontiers in neuroscience · 2026Pooled it
- A comparison between children and adolescents with autism spectrum disorders and healthy controls in biomedical factors, trace elements, and microbiota biomarkers: a meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Randomized, Double-Blind, Placebo-Controlled Trial of the Probiotic Lactiplantibacillus plantarum Probio87 for Gut-Vaginal Microbiota Modulation in Healthy Women.Molecular nutrition & food research · 2026Trial
- Oral intake ofNutrients · 2023Trial
- Functional Heterogeneity of the Autism Spectrum Disorder-Associated Gut Microbial Ecosystem Revealed by Fecal Lipopolysaccharides and Bacterial Proteomic Profiling.Chembiochem : a European journal of chemical biology · 2026Article
- Community Structure and Functional Prediction of Gut Microbiota in Mandarin Fish (Siniperca Chuatsi) Under Different Culture and Feeding Conditions.Life (Basel, Switzerland) · 2026Article
- Article
- Gut Microbiota and Mitochondrial Dysfunction in Autism: Clinical Correlations and Future Directions.Molecular neurobiology · 2026Review
- Advances in understanding intestinal microbiota mechanisms and intervention strategies for anxiety, depression, sleep disorders, and constipation.Frontiers in microbiology · 2026Review
- The gut microbiota and sleep in infants: a focus on diurnal rhythmicity patterns.Gut microbes reports · 2026Article
- Gut microbiome dynamics in autism: a prospective nested case-control study demonstrates microbial-clinical associations following rehabilitation interventions.Frontiers in neuroscience · 2026Article
- Gut microbiota in genetic diseases: from Mendelian disorders to complex traits.Frontiers in immunology · 2026Review
- The Microbial Factors, Trace Elements, and Important Biological Indicators in Children with Autism Spectrum Disorder: A Meta-Analysis.Iranian journal of public health · 2025Review
- Association Between Sleep Disturbance and Behavioral Feeding Problems in Children and Adolescents with Autism Spectrum Disorder.Diseases (Basel, Switzerland) · 2025Article
- Gut microbiota distinguishes aging hispanics with Alzheimer's disease: associations with cognitive impairment and severity.Scientific reports · 2025Article
- The Role of Gut Microbiota in Insomnia: A Systematic Review of Case-Control Studies.Life (Basel, Switzerland) · 2025Review
- Identification of enterotype for patients with Alzheimer's disease.Journal of translational medicine · 2025Article
- Research progress on melatonin, 5-HT, and orexin in sleep disorders of children with autism spectrum disorder.Biomolecules & biomedicine · 2025Review
- Chemotherapy-induced suppression of colorectal cancer-associated gut microbiota and modulation of host miRNA expression.American journal of translational research · 2025Article
- The Impact of Probiotic Supplementation on the Sleep Quality of Humans: A Review of Results of Randomized, Blinded, Controlled Studies.Current pharmaceutical design · 2025Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorder (ASD) is a type of neurodevelopmental disease that is frequently accompanied by sleep disorder. Herein, we investigated changes in the gut microbiota and its metabolites correlated with core symptoms and sleep problems in children with ASD.
methodsOne hundred and twenty children diagnosed with ASD based on Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria were enrolled in our study. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood Autism Rating Scale (CARS) were used to assess autism symptoms, and the Children Sleep Habits Questionnaire (CSHQ) was employed to evaluate sleep problems in children with ASD. The 120 children were divided into a sleep disorder group (n = 60) and a control group without sleep disorder (n = 60) according to the CSHQ answers. Illumina MiSeq analysis of 16S rRNA genes was used to compare differences in gut microbiota, and metabolomics analysis was employed to asses associated metabolites.
resultsSRS and CARS scores for the sleep disorder group were significantly higher than for the control group (
conclusionsASD children with sleep disorder exhibited declines in the abundance of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.