Evidence map›Paper›PMID 32982768›Full record

ReviewFrontiers in physiology2020

Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation.

Mehrdad Pourfathi, Stephen J Kadlecek, Shampa Chatterjee, Rahim R Rizi

Registry-linked trialAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05101694 (Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05101694 unknown statusnot on this mapstarted 2022, after this paper: background citation

Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS

Typeobservational_patient_registrySponsorSoutheast University, ChinaRan2022 to 2023Enrolled60ConditionsARDS
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Article
  5. Multinuclear MRI in Drug Discovery.Molecules (Basel, Switzerland) · 2022
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mehrdad PourfathiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, United States.
Stephen J KadlecekDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, United States.
Shampa ChatterjeeDepartment of Physiology, University of Pennsylvania, Philadelphia, PA, United States.
Rahim R RiziDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, United States.

Funding

Assessment of Lung Injury with integrated Imaging TechniquesR01HL139066 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RIZI, RAHIM R · 2017 to 2020
$2.4M
NHLBI NIH HHS R01 HL139066
6 · The paper itself

Abstract

Pulmonary inflammation is a hallmark of several pulmonary disorders including acute lung injury and acute respiratory distress syndrome. Moreover, it has been shown that patients with hyperinflammatory phenotype have a significantly higher mortality rate. Despite this, current therapeutic approaches focus on managing the injury rather than subsiding the inflammatory burden of the lung. This is because of the lack of appropriate non-invasive biomarkers that can be used clinically to assess pulmonary inflammation. In this review, we discuss two metabolic imaging tools that can be used to non-invasively assess lung inflammation. The first method, Positron Emission Tomography (PET), is widely used in clinical oncology and quantifies flux in metabolic pathways by measuring uptake of a radiolabeled molecule into the cells. The second method, hyperpolarized

Indexed as

ARDSFDG-PETHP-MRIlung inflammationlung injury

Identifiers

PMID32982768
PMCPMC7487972

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.