ArticleFrontiers in neuroinformatics2020
Disrupted Rich Club Organization of Hemispheric White Matter Networks in Bipolar Disorder.
Article in Frontiers in neuroinformatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Hemispheric Asymmetries in Bipolar Disorder: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia.Biological psychiatry global open science · 2024Article
- Altered structural connectome of children with auditory processing disorder: a diffusion MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging studies suggest disrupted connections of the brain white matter (WM) network in bipolar disorder (BD). A group of highly interconnected high-density structures, termed the 'rich club,' represents an important network for brain functioning. Recent works have revealed abnormal rich club organization in brain networks in BD. However, little is known regarding changes in the rich club organization of the hemispheric WM network in BD. Forty-nine BD patients and fifty-five age- and sex-matched normal controls (NCs) underwent diffusion tensor imaging (DTI). Graph theory approaches were applied to quantify group-specific rich club organization and nodal degree of hemispheric WM networks. We demonstrated that rich club organization of hemispheric WM networks in BD was disrupted, with disrupted feeder and local connections among hub and peripheral regions located in the default mode network (DMN) and the control execution network (CEN). In addition, BD patients showed abnormal asymmetry in the feeder and local connections, involving the hub and peripheral regions associated with emotion regulation and visuospatial functions. Moreover, the clinical symptoms of BD showed a significant correlation with the aberrant asymmetry in the regional degree of peripheral regions. These findings reveal that BD is closely associated with disrupted feeder and local connections but no alteration in rich-club connections in the rich club organization of hemispheric WM networks and provide novel insight into the changes of brain functions in BD.
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Registered trials
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