Evidence map›Paper›PMID 32982698›Full record

ArticleFrontiers in neural circuits2020

Why Brain Criticality Is Clinically Relevant: A Scoping Review.

Vincent Zimmern

Abstract readScoping Review
In one paragraph

Article in Frontiers in neural circuits, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The entropic brain today.Brain : a journal of neurology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Hierarchical whole-brain modeling of critical synchronization dynamics in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Emergent critical oscillations in motor cortex of Parkinson's patients.bioRxiv : the preprint server for biology · 2026
    Article
  12. Critical Dynamics in the Association Cortex Predict Higher Intelligence in Typically Developing Children.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Criticality and increased intrinsic neural timescales in stroke.NPJ systems biology and applications · 2025
    Article
  18. Review
  19. Ephaptic coupling and power fluctuations in depression.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Vincent ZimmernDivision of Child Neurology, The University of Texas Southwestern Medical Center, Dallas, TX, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The past 25 years have seen a strong increase in the number of publications related to criticality in different areas of neuroscience. The potential of criticality to explain various brain properties, including optimal information processing, has made it an increasingly exciting area of investigation for neuroscientists. Recent reviews on this topic, sometimes termed brain criticality, make brief mention of clinical applications of these findings to several neurological disorders such as epilepsy, neurodegenerative disease, and neonatal hypoxia. Other clinicallyrelevant domains - including anesthesia, sleep medicine, developmental-behavioral pediatrics, and psychiatry - are seldom discussed in review papers of brain criticality. Thorough assessments of these application areas and their relevance for clinicians have also yet to be published. In this scoping review, studies of brain criticality involving human data of all ages are evaluated for their current and future clinical relevance. To make the results of these studies understandable to a more clinical audience, a review of the key concepts behind criticality (e.g., phase transitions, long-range temporal correlation, self-organized criticality, power laws, branching processes) precedes the discussion of human clinical studies. Open questions and forthcoming areas of investigation are also considered.

Indexed as

BrainHumansModels, NeurologicalModels, Theoreticalanesthesiabraincriticalityepilepsylong-range temporal correlationneurodegenerationneurodevelopmentsleep

Identifiers

PMID32982698
PMCPMC7479292

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.