Evidence map›Paper›PMID 32982688›Full record

ArticleFrontiers in molecular neuroscience2020

Ultra-Endurance Associated With Moderate Exercise in Rats Induces Cerebellar Oxidative Stress and Impairs Reactive GFAP Isoform Profile.

Raphael Fabricio de Souza, Ricielle Lopes Augusto, Silvia Regina Arruda de Moraes, Fabio Borges de Souza, Lílian Vanessa da Penha Gonçalves, Danielle Dutra Pereira, Gisele Machado Magalhães Moreno, Fernanda Maria Araujo de Souza, Belmira Lara da Silveira Andrade-da-Costa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Raphael Fabricio de SouzaLaboratory of Neurophysiology, Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Ricielle Lopes AugustoLaboratory of Neurophysiology, Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Silvia Regina Arruda de MoraesLaboratory of Neuromuscular Plasticity, Department of Anatomy, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Fabio Borges de SouzaLaboratory of Neurophysiology, Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Lílian Vanessa da Penha GonçalvesLaboratory of Neurophysiology, Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Danielle Dutra PereiraLaboratory of Neurophysiology, Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Gisele Machado Magalhães MorenoLaboratory of Neurophysiology, Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Fernanda Maria Araujo de SouzaLaboratory of Neuropharmacology and Integrative Physiology, Center of Biosciences, Federal University of Alagoas, Maceió, Brazil.
Belmira Lara da Silveira Andrade-da-CostaLaboratory of Neurophysiology, Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Universidade Federal de Pernambuco · BRUniversidade Federal de Alagoas · BRUniversidade Federal de Sergipe · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultra-endurance (UE) race has been associated with brain metabolic changes, but it is still unknown which regions are vulnerable. This study investigated whether high-volume training in rodents, even under moderate intensity, can induce cerebellar oxidative and inflammatory status. Forty-five adult rats were divided into six groups according to a training period, followed or not by an exhaustion test (ET) that simulated UE: control (C), control + ET (C-ET), moderate-volume (MV) training and MV-ET, high-volume training (HV) and HV-ET. The training period was 30 (MV) and 90 (HV) min/day, 5 times/week for 3 months as a continuous running on a treadmill at a maximum velocity of 12 m/min. After 24 h, the ET was performed at 50% maximum velocities up to the animals refused to run, and then serum lactate levels were evaluated. Serum and cerebellar homogenates were obtained 24 h after ET. Serum creatine kinase (CK), lactate dehydrogenase (LDH), and corticosterone levels were assessed. Lipid peroxidation (LP), nitric oxide (NO), Interleukin 1β (IL-1β), and GFAP proteins, reduced and oxidized glutathione (GSH and GSSG) levels, superoxide dismutase (SOD) and catalase (CAT) activities were quantified in the cerebellum. Serum lactate concentrations were lower in MV-ET (∼20%) and HV-ET (∼40%) compared to the C-ET group. CK and corticosterone levels were increased more than ∼ twofold by HV training compared to control. ET increased CK levels in MV-ET vs. MV group (

Indexed as

catalasecentral nervous systemglial fibrillary acidic proteinhigh-volume traininglipid peroxidationoxidative stresssuperoxide dismutase

Identifiers

PMID32982688
PMCPMC7492828
OpenAlexW3081702269

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.