ReviewFrontiers in neuroscience2020
The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer's Disease.
Review in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- The association between restless legs syndrome and chronic venous insufficiency: a systematic review.Journal of medicine and life · 2025Pooled it
- HSV-1 reactivation as an emergent property of neuronal stress: implications for traumatic brain injury.Journal of neuroinflammation · 2026Review
- Integration of Transcriptomics With Interpretable Artificial Intelligence for Identifying Molecular Signatures of Physiological Stress in Sleep Deprivation.Journal of cellular and molecular medicine · 2026Article
- Neutrophil inflammation metrics are associated with the risk of future dementia in large data from NYU Langone Hospitals and the Veterans Health Administration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- From Traumatic Brain Injury to Alzheimer's Disease: Multilevel Biomechanical, Neurovascular, and Molecular Mechanisms with Emerging Therapeutic Directions.International journal of molecular sciences · 2026Review
- Sleep fragmentation intensifies sleep architecture disruption and fatigue after traumatic brain injury.Experimental neurology · 2026Article
- Single-Cell eQTL Revealing Brain Cell-Type-Specific Genetic Control of Insomnia.Journal of molecular neuroscience : MN · 2026Article
- Association between adherence to Dietary Approach to Stop Hypertension (DASH) diet with sleep quality, sleep duration, inflammation, and oxidative stress among Iranian adults.Journal of translational medicine · 2025Article
- Calcitonin Gene-Related Peptide (CGRP)-Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain-Induced Sleep Disturbances.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The glymphatic and meningeal lymphatic systems may converge, connecting traumatic brain injury progression with chronic traumatic encephalopathy onset.Molecular and cellular neurosciences · 2025Review
- The Clock and the Brain: Circadian Rhythm and Alzheimer's Disease.Current issues in molecular biology · 2025Review
- Deprivation and well-being in squalid living: a propensity score matched cross-sectional study of the English Housing Survey.BMC public health · 2025Article
- Traumatic brain injury graphing: A case study of Charles Whitman.Journal of forensic sciences · 2025Article
- Sleep and immune health: How dogs, goats and 'factor S' shaped a field.Neurobiology of sleep and circadian rhythms · 2025Article
- Microglial depletion and repopulation differentially modulate sleep and inflammation in a mouse model of traumatic brain injury.Neurobiology of sleep and circadian rhythms · 2025Article
- Impacts of traumatic brain injury severity and sex on sleep architecture, duration, and fragmentation.Neurobiology of sleep and circadian rhythms · 2025Article
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Sleep Fragmentation as a Diagnostic Biomarker of Traumatic Brain Injury.Neurotrauma reports · 2025Article
- Impact of Mild Traumatic Brain Injury on Sleep Patterns in Younger Individuals: A Systematic Review.Neurotrauma reports · 2025Review
- Identifying the Brain Circuits that Regulate Pain-Induced Sleep Disturbances.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) and Alzheimer's disease (AD) are diseases during which the fine-tuned autoregulation of the brain is lost. Despite the stark contrast in their causal mechanisms, both TBI and AD are conditions which elicit a neuroinflammatory response that is coupled with physical, cognitive, and affective symptoms. One commonly reported symptom in both TBI and AD patients is disturbed sleep. Sleep is regulated by circadian and homeostatic processes such that pathological inflammation may disrupt the chemical signaling required to maintain a healthy sleep profile. In this way, immune system activation can influence sleep physiology. Conversely, sleep disturbances can exacerbate symptoms or increase the risk of inflammatory/neurodegenerative diseases. Both TBI and AD are worsened by a chronic pro-inflammatory microenvironment which exacerbates symptoms and worsens clinical outcome. Herein, a positive feedback loop of chronic inflammation and sleep disturbances is initiated. In this review, the bidirectional relationship between sleep disturbances and inflammation is discussed, where chronic inflammation associated with TBI and AD can lead to sleep disturbances and exacerbated neuropathology. The role of microglia and cytokines in sleep disturbances associated with these diseases is highlighted. The proposed sleep and inflammation-mediated link between TBI and AD presents an opportunity for a multifaceted approach to clinical intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.