Evidence map›Paper›PMID 32982626›Full record

ArticleAdvanced functional materials2020

Porous Silicon Nanoparticles Embedded in Poly(lactic-

Jonathan M Zuidema, Courtney M Dumont, Joanna Wang, Wyndham M Batchelor, Yi-Sheng Lu, Jinyoung Kang, Alessandro Bertucci, Noel M Ziebarth, Lonnie D Shea, Michael J Sailor

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. PTEN: a new dawn in Parkinson's disease treatment.Frontiers in cellular neuroscience · 2025
    Review
  4. Article
  5. Harnessing the Materials Chemistry of Mesoporous Silicon Nanoparticles to Prepare "Armor-Clad" Enzymes.Chemistry of materials : a publication of the American Chemical Society · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Nanofiber Carriers of Therapeutic Load: Current Trends.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jonathan M ZuidemaDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Courtney M DumontDepartment of Biomedical Engineering, University of Miami, 1251 Memorial Drive, Coral Gables, FL 33146, USA.
Joanna WangMaterials Science and Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Wyndham M BatchelorDepartment of Biomedical Engineering, University of Miami, 1251 Memorial Drive.
Yi-Sheng LuMaterials Science and Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Jinyoung KangDepartment of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, CA.
Alessandro BertucciDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Noel M ZiebarthDepartment of Biomedical Engineering, University of Miami, 1251 Memorial Drive.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Boulevard, Ann Arbor, MI 48109, USA.
Michael J SailorDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
University of California San Diego · USUniversity of Miami · USUniversity of Michigan · USUniversity of Rome Tor Vergata · IT

Funding

Controlled Release Scaffolds for Nerve RegenerationR01EB005678 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDERSON, AILEEN J, SHEA, LONNIE D · 2007 to 2018
$6.0M
Multi-channeled Bridges for Promoting Chronic Spinal Cord RepairR01NS117103 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDERSON, AILEEN J, CUMMINGS, BRIAN JOHN · 2020 to 2024
$2.1M
Cancer Researchers in Nanotechnology (CRIN)T32CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, ZHANG, DONG-ER · 2017 to 2021
$994k
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
NCI NIH HHS T32 CA153915NIBIB NIH HHS R01 EB005678NIH HHS S10 OD023527NINDS NIH HHS R01 NS117103
6 · The paper itself

Abstract

Scaffolds made from biocompatible polymers provide physical cues to direct the extension of neurites and to encourage repair of damaged nerves. The inclusion of neurotrophic payloads in these scaffolds can substantially enhance regrowth and repair processes. However, many promising neurotrophic candidates are excluded from this approach due to incompatibilities with the polymer or with the polymer processing conditions. This work provides one solution to this problem by incorporating porous silicon nanoparticles (pSiNPs) that are pre-loaded with the therapeutic into a polymer scaffold during fabrication. The nanoparticle-drug-polymer hybrids are prepared in the form of oriented poly(lactic-

Indexed as

controlled releaseNerve Growth Factorneuron guidancePTEN inhibitorRNAaptamertissue engineeringtropomyosin-related kinase receptor type B

Identifiers

PMID32982626
PMCPMC7513949
OpenAlexW3023504943

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.