ArticleDrug, healthcare and patient safety2020
Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, Ethiopia.
Article in Drug, healthcare and patient safety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Inappropriate antibiotic prescribing in Ethiopian hospitals: a systematic review.International journal of clinical pharmacy · 2026Pooled it
- Inappropriate ceftriaxone utilization and predictor factors in Ethiopia: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Evaluation of inpatient antibiotic prescribing patterns using WHO indicators in Northern Ethiopia: a prospective cross-sectional study identifying stewardship gaps.BMC research notes · 2026Article
- Drug use patterns at a Kenyan referral hospital: A cross-sectional study using WHO core indicators.PloS one · 2026Article
- Observational
- Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs.Infection and drug resistance · 2025Article
- A high prevalence of antibiotic use at two large teaching hospitals in Addis Ababa, Ethiopia: a point prevalence survey.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Ceftriaxone Use Evaluation in Western Zone Tigray Hospitals, Ethiopia: A Retrospective Cross-Sectional Study.BioMed research international · 2023Article
- Has the COVID-19 Pandemic Impacted Healthcare Service Uptake at Hospitals in Addis Ababa?Ethiopian journal of health sciences · 2021Article
- Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda.Antibiotics (Basel, Switzerland) · 2021Article
- Appropriate Use of Ceftriaxone in Sub-Saharan Africa: A Systematic Review.Infection and drug resistance · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCeftriaxone is one of the most commonly used antibiotics due to its availability, wide spectrum of activity and low toxicity. However, irrational use of ceftriaxone is one of the current issues in most countries, especially developing ones.
objectiveThe aim of this study was to evaluate ceftriaxone utilization in different wards of Ras-Desta Memorial General Hospital (RDMGH) in Ethiopia.
methodsAn institution-based retrospective cross-sectional study was conducted on randomly selected 1,079 patients who were admitted to RDMGH from May 2017 to April 2018. A structured data abstraction format was used to collect data from patients' medical chart. Micromedex® drug interaction checker was used to identify significant drug-drug interactions, and national and international guidelines were used to evaluate the appropriateness of ceftriaxone use. The data were analyzed by using SPSS version 20.0.
resultsAmong the 1,079 patients enrolled, ceftriaxone was utilized by 601 (55.7%) patients, and these patients were considered for evaluation of appropriateness and subsequent analysis. Among 601 patients, ceftriaxone was used for therapeutic purpose in 362 (60.2%) patients; of which, 359 (99.2%) were for empiric therapy and the rest 239 (39.8%) were for prophylaxis. In the majority of the patients, the dose of ceftriaxone was 2g/day 472 (78.6%) and for a duration of 2-7 days 409 (68.1%). Inappropriate use of ceftriaxone was observed among 237 (39.4%) patients with regard to indication, dose/frequency and duration. About half (49.3%) of the deviation from the guidelines was observed from surgical and gynecologic/obstetrics wards. Among the co-prescribed medications with ceftriaxone, ringer lactate, warfarin and heparin were found to have a significant drug-drug interaction.
conclusionThis study revealed that inappropriate use of ceftriaxone was high in RDMGH. This may increase the emergence of resistant pathogens which may lead to treatment failure and increase cost of therapy. Therefore, adherence to current evidence-based guidelines is recommended.
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