Evidence map›Paper›PMID 32982163›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2020

The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery.

John Hovanesian, Alice Epitropoulos, Eric D Donnenfeld, Jack T Holladay

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06656403 (Effect of Artificial Tears on Ocular Biometry Parameters), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06656403 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Artificial Tears on Ocular Biometry Parameters

TypeinterventionalSponsorHe Eye HospitalRan2024 to 2024Enrolled100ConditionsDry Eye Disease, Tear FilmArms0.1% sodium hyaluronate
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Clinical Efficacy of an Eyedrop Containing Hyaluronic Acid and Ginkgo Biloba in the Management of Dry Eye Disease Induced by Cataract Surgery.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2022
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  5. Unveiling dry eye disease prior to cataract surgery: A multicenter clinical study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

John HovanesianHarvard Eye Associates, Laguna Hills, CA, USA.ORCID 0000-0001-8060-8750
Alice EpitropoulosOphthalmic Surgeons & Consultants of Ohio, Columbus, OH, USA.ORCID 0000-0001-9037-9605
Eric D DonnenfeldOphthalmic Consultants of Long Island, Garden City, NY, USA.ORCID 0000-0002-5235-1780
Jack T HolladayBaylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4609-5522
Baylor College of Medicine · USHarvard Eye Associates · USOphthalmic Consultants of Long Island · USSociety of Thoracic Surgeons · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the effect of lifitegrast ophthalmic solution 5% on improving the tear film, biometry/keratometry, and refractive accuracy for dry eye patients scheduled for cataract surgery. PATIENTS AND

methodsMulticenter, prospective, open-label study of 100 eyes of 100 patients undergoing cataract surgery who had a confirmed diagnosis of dry eye. Patients underwent biometry at baseline and again after a 28-day course of lifitegrast 5% BID. Primary outcome was an improvement in the accuracy of preoperative anterior corneal power measurements at predicting postoperative spherical equivalent (SE) pre- and post-lifitegrast treatment. Secondary outcomes included changes in dry eye symptoms and corneal staining.

resultsThe accuracy of the biometry readings for the achieved refractive SE: within 0.25 D in 47% and 50% of eyes before and after the initial lifitegrast treatment, respectively; within 0.5 D in 71% and 79% of eyes before and after the initial lifitegrast treatment; and within 0.75 D in 81% and 91% of eyes before and after the initial lifitegrast treatment (p < 0.04).

conclusionLifitegrast 5% significantly improved preoperative corneal surface measurement accuracy in patients with confirmed dry eye who were scheduled for cataract surgery.

Indexed as

cataract surgerydry eyehigher-order aberrationslifitegrast

Identifiers

PMID32982163
PMCPMC7502384
OpenAlexW3084465191

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.