Evidence map›Paper›PMID 32982003›Full record

ArticleSouth African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges2021

Alkaloids of

Karen Acosta León, Alexandra Inca, Luciana R Tallini, Edison H Osorio, Jessica Robles, Jaume Bastida, Nora H Oleas

Open access · hybridAbstract read
In one paragraph

Article in South African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Chemical Survey of Three Species of the GenusPlants (Basel, Switzerland) · 2022
    Article
  6. Article
  7. Review
  8. Structural Diversity and Biological Potential of Alkaloids from the GenusRevista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Karen Acosta LeónGrupo de Investigación de Productos Naturales y Farmacia, Facultad de Ciencias, Escuela Superior Politécnica del Chimborazo, Panamericana Sur km 1 1/2, Riobamba EC060155, Ecuador.
Alexandra IncaGrupo de Investigación de Productos Naturales y Farmacia, Facultad de Ciencias, Escuela Superior Politécnica del Chimborazo, Panamericana Sur km 1 1/2, Riobamba EC060155, Ecuador.
Luciana R TalliniGrup de Productes Naturals, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.
Edison H OsorioFacultad de Ciencias Naturales y Matemáticas, Universidad de Ibagué, Carrera 22 Calle 67, Ibagué 730001, Colombia.
Jessica RoblesGrupo de Investigación de Productos Naturales y Farmacia, Facultad de Ciencias, Escuela Superior Politécnica del Chimborazo, Panamericana Sur km 1 1/2, Riobamba EC060155, Ecuador.
Jaume BastidaGrup de Productes Naturals, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.
Nora H OleasCentro de Investigación de la Biodiversidad y Cambio Climático (BioCamb) e Ingeniería en Biodiversidad y Recursos Genéticos, Facultad de Ciencias de Medio Ambiente, Universidad Tecnológica Indoamérica, Machala y Sabanilla, Quito EC170301, Ecuador.
Escuela Superior Politécnica del Chimborazo · ECUniversidad de Ibagué · COUniversidade Federal do Rio Grande do Sul · BRUniversidad Indoamérica · ECUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is considered the most common cause of dementia and, in an increasingly aging population worldwide, the quest for treatment is a priority. Amaryllidaceae alkaloids are of main interest because of their cholinesterase inhibition potential, which is the main palliative treatment available for this disease. We evaluated the alkaloidal profile and the

Indexed as

AChEAChE, AcetylcholinesteraseAE, alkaloid extractAlkaloidsAlzheimer's diseaseAmaryllidaceaeATCI, acetylthiocholine iodideBTCI, butyrylthiocholine iodideBuChEBuChE, butyrylcholinesteraseCD, circular dichroismDTNB, (5,5′-dithio-bis-[2-nitrobenzoic acid])Et2O, diethyl etherEtOAc, ethyl acetateGAL, galanthamineGC-MS, gas chromatography coupled to mass spectrometryIUCN, International Union for Conservation of NatureMeOH, methanolMolecular dockingMS, mass spectrometryNMR, nuclear magnetic resonancePhaedranassaUV, ultraviolet

Identifiers

PMID32982003
PMCPMC7500283
OpenAlexW3087087172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.