Evidence map›Paper›PMID 32981913›Full record

ArticleJournal of clinical and experimental hematopathology : JCEH2020

Uterine relapse of Philadelphia chromosome-negative acute lymphoblastic leukemia.

Noriaki Kawano, Tetsuo Maeda, Sayaka Kawano, Yuri Naghiro, Akiyoshi Takami, Taro Tochigi, Takashi Nakaike, Kiyoshi Yamashita, Takao Kodama, Kosuke Marutsuka and 8 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hematopathology : JCEH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Noriaki KawanoDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Tetsuo MaedaDepartment of Hematology, University of Osaka, Osaka, Japan.
Sayaka KawanoDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Yuri NaghiroDepartment of Psychiatry, Jozan Hospital, Kumamoto, Japan.
Akiyoshi TakamiDivision of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
Taro TochigiDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Takashi NakaikeDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Kiyoshi YamashitaDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Takao KodamaDepartment of Radiology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Kosuke MarutsukaDepartment of Pathology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Yuka SugimotoDepartment of Hematology, University of Mie, Mie, Japan.
Toshihiko ImamuraDepartment of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Yasuo MoriDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Hidenobu OchiaiTrauma and Critical Care Center, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Tomonori HidakaDivision of Gastroenterology and Hematology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kazuya ShimodaDivision of Gastroenterology and Hematology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Koichi MashibaDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Ikuo KikuchiDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
Miyazaki Prefectural Hospital · JPUniversity of Miyazaki · JPAichi Medical University · JPKyoto Prefectural University of Medicine · JPKyushu University · JPMie University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relapse of acute lymphoblastic leukemia (ALL) usually involves the bone marrow, with the central nervous system being the most frequent extramedullary site. The relapse of ALL in the female genital organs, particularly the uterus, is markedly rare. We report such a patient who developed relapse in the bone marrow and uterus. The uterine lesion, which presented as abnormal uterine bleeding, consisted of a mass on MRI and proliferation of ALL cells on histology. MRI revealed a heterogeneous high-intensity mass (T2-WI/D-WI) with a diameter of 6.8 cm, a notable decrease in the apparent diffusion coefficient (ADC), and mild enhancement by contrast enhancement study. Histological findings of the uterine cervix demonstrated the infiltration of ALL. The patient achieved remission by allogeneic haplo-identical hematopoietic stem-cell transplantation, but died of complications of the transplantation. This case suggested that attention should be paid to the uterus as a site of extramedullary relapse. In addition, abnormal uterine bleeding, which is a common sign of hormonal imbalance and hormone replacement therapy after chemotherapy, may be an initial sign of extramedullary recurrence. To confirm uterine relapse as an intractable disease, the accumulation of more cases is required.

Indexed as

Bone MarrowFemaleHumansKaryotypeMiddle AgedNeoplasm Recurrence, LocalPhiladelphia ChromosomePrecursor Cell Lymphoblastic Leukemia-LymphomaUterine NeoplasmsUterusMRI featuresPhiladelphia-negative B-ALLrefractory clinical courseuterine relapse

Identifiers

PMID32981913
PMCPMC7596908
OpenAlexW3088549610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.