ArticleEndocrinology and metabolism (Seoul, Korea)2020
Effects of Systemic Glucocorticoid Use on Fracture Risk: A Population-Based Study.
Article in Endocrinology and metabolism (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Low-dose, not low-risk: potential adrenal suppression identified by a risk-based approach to ACTH testing.Clinical rheumatology · 2026Observational
- Primary hyperparathyroidism presenting as atraumatic bilateral hip fractures: a case report.Journal of medical case reports · 2026Article
- Association between femoral localized cortical thickening ("beaking" or "flaring") and bisphosphonate duration in glucocorticoid-induced osteoporosis.Journal of bone and mineral metabolism · 2026Article
- Sex differences in clinical and metabolic outcomes of glucocorticoid replacement therapy in adrenal insufficiency.Pituitary · 2026Review
- Plant-derived extracellular vesicles as tools and targets for inflammatory diseases.Journal of nanobiotechnology · 2026Review
- Review
- The link between osteoporosis and cardiovascular diseases: a review of shared mechanisms, risk factors, and therapeutic approaches.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Effectiveness of biological therapy in severe asthma: a retrospective real-world study.Croatian medical journal · 2025Article
- Incidence, prevalence, and predictors of osteoporotic fracture in adult lung transplant recipients.JHLT open · 2025Article
- Low-dose glucocorticoid increase the risk of fracture in postmenopausal women with low bone mass: a retrospective cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Bad to the bones: prescribing of drugs for the prevention and treatment of osteoporosis in patients on chronic glucocorticoids.Archives of osteoporosis · 2023Article
- Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study.Frontiers in endocrinology · 2023Article
- Article
- Why Do We Need Proactive Management for Fracture Prevention in Long-Term Glucocorticoid Users?Endocrinology and metabolism (Seoul, Korea) · 2020Article
- Underutilization of Osteoporosis Screening in Patients With Severe COPD and Long Term Corticosteroid Use.Journal of primary care & community healthArticle
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8 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundLong-term glucocorticoid use increases fracture risk by reducing bone mass. This study evaluated the relationship between hip and vertebral fractures and the total amount of systematic glucocorticoid use.
methodsWe randomly selected 1,896,159 people aged 20 to 100 years who participated in the National Health Checkup program in 2006. The amount of glucocorticoids prescribed was calculated based on the defined daily dose (DDD). The total DDD was obtained by adding oral and parenteral glucocorticoids for 6 months from the index date. Subjects were categorized into four groups according to total glucocorticoid DDDs: non-users (DDDs=0), low users (0< DDDs ≤45), intermediate users (45< DDDs ≤90), and high users (90< DDDs). We followed them for 2 years. A multivariate Cox proportional hazard model was used to evaluate the effects of the total amount of glucocorticoid use on hip and vertebral fractures.
resultsHigher glucocorticoid use was associated with a higher risk of vertebral fracture. Relative to non-users, the vertebral fracture risk was 1.39 times higher in the low-user group, 1.94 times higher in the intermediate-user group, and 2.43 times higher in the highuser group. The risk of hip fracture was 1.72 times higher in intermediate users and 3.28 times higher in high users than in non-users.
conclusionAs the amount of glucocorticoid use for 6 months increased, the risk of hip and vertebral fractures became higher. In order to prevent fractures, it is necessary for doctors to evaluate the total amount of glucocorticoid prescribed to the patient and to provide appropriate treatment.
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