ArticlePlant biotechnology journal2021
GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 29 citations in OpenAlex.
- Genetic Mapping and Functional Characterisation of GhCUP Regulating Leaf Curling in Cotton.Plant biotechnology journal · 2026Article
- Article
- Homeodomain leucine zipper protein controls the lobed leaf formation by modulating auxin distribution in watermelon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The GhWL1-GhH1-GhGA2OX1 Transcriptional Module Regulates Cotton Leaf Morphology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genetic mapping and transcriptome profiling revealed leaf lobe formation and leaf size are regulated by GhRlTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Cotton GhMAX2 promotes single-celled fiber elongation by releasing the GhS1FA-mediated inhibition of fatty acid biosynthesis.Plant cell reports · 2025Article
- Strigolactone-induced degradation of SMXL7 and SMXL8 contributes to gibberellin- and auxin-mediated fiber cell elongation in cotton.The Plant cell · 2024Article
- Cotton BLH1 and KNOX6 antagonistically modulate fiber elongation via regulation of linolenic acid biosynthesis.Plant communications · 2024Article
- The 4Fs of cotton: genome editing of cotton for fiber, food, feed, and fuel to achieve zero hunger.Frontiers in genome editing · 2024Review
- Formation mechanism and regulation analysis of trumpet leaf inFrontiers in plant science · 2024Article
- A comprehensive overview of cotton genomics, biotechnology and molecular biological studies.Science China. Life sciences · 2023Review
- Article
- Enhanced genome-wide association reveals the role of YABBY11-NGATHA-LIKE1 in leaf serration development of Populus.Plant physiology · 2023Article
- GhBZR3 suppresses cotton fiber elongation by inhibiting very-long-chain fatty acid biosynthesis.The Plant journal : for cell and molecular biology · 2022Article
- Chromosome-Level Genome Assembly forFrontiers in plant science · 2022Article
- Molecular mechanism of leaf adaxial upward curling caused byFrontiers in plant science · 2022Article
- Molecular Mechanisms of Plant Trichome Development.Frontiers in plant science · 2022Review
- GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton.Plant biotechnology journal · 2021Article
- Evolutionary Relationships and Divergence of KNOTTED1-Like Family Genes Involved in Salt Tolerance and Development in Cotton (Frontiers in plant science · 2021Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The leaf is a crucial organ evolved with remarkable morphological diversity to maximize plant photosynthesis. The leaf shape is a key trait that affects photosynthesis, flowering rates, disease resistance and yield. Although many genes regulating leaf development have been identified in the past years, the precise regulatory architecture underlying the generation of diverse leaf shapes remains to be elucidated. We used cotton as a reference model to probe the genetic framework underlying divergent leaf forms. Comparative transcriptome analysis revealed that the GhARF16-1 and GhKNOX2-1 genes might be potential regulators of leaf shape. We functionally characterized the auxin-responsive factor ARF16-1 acting upstream of GhKNOX2-1 to determine leaf morphology in cotton. The transcription of GhARF16-1 was significantly higher in lobed-leaved cotton than in smooth-leaved cotton. Furthermore, the overexpression of GhARF16-1 led to the up-regulation of GhKNOX2-1 and resulted in more and deeper serrations in cotton leaves, similar to the leaf shape of cotton plants overexpressing GhKNOX2-1. We found that GhARF16-1 specifically bound to the promoter of GhKNOX2-1 to induce its expression. The heterologous expression of GhARF16-1 and GhKNOX2-1 in Arabidopsis led to lobed and curly leaves, and a genetic analysis revealed that GhKNOX2-1 is epistatic to GhARF16-1 in Arabidopsis, suggesting that the GhARF16-1 and GhKNOX2-1 interaction paradigm also functions to regulate leaf shape in Arabidopsis. To our knowledge, our results uncover a novel mechanism by which auxin, through the key component ARF16-1 and its downstream-activated gene KNOX2-1, determines leaf morphology in eudicots.
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