ArticleClinical and experimental medicine2021
Thyroid peroxidase in human endometrium and placenta: a potential target for anti-TPO antibodies.
Article in Clinical and experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Prevalence of thyroid autoantibody positivity in women with infertility: a systematic review and meta-analysis.BMC women's health · 2024Pooled it
- Impact of autoimmune thyroiditis on IVF outcomes in patients with polycystic ovary syndrome and chronic endometritis.Journal of ovarian research · 2026Article
- Active Antibiotic Treatment Improves ART Outcomes in TPOAb-Positive Chronic Endometritis Patients: A Retrospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- A study of the association between the early pregnancy thrombosis-thyroid axis and pregnancy outcomes in patients with recurrent spontaneous abortion.Frontiers in endocrinology · 2026Article
- Infertility and Auto-Antibodies: A Review.Antibodies (Basel, Switzerland) · 2025Review
- Analysis of the influencing factors for adverse reproductive outcomes in patients with positive TPOAb and the establishment of a nomogram prediction model.Scientific reports · 2025Article
- Evaluating the tissue expression of thyroid peroxidase in chronic spontaneous urticaria patients.Archives of dermatological research · 2025Article
- Article
- Impact of Systemic Lupus Erythematosus on Conception: Insights into Infertility, Fertility Preservation, Assisted Reproductive Technology, and Pregnancy Outcomes.Seminars in reproductive medicine · 2024Review
- B cells: roles in physiology and pathology of pregnancy.Frontiers in immunology · 2024Review
- Article
- Thyroid autoimmunity and its negative impact on female fertility and maternal pregnancy outcomes.Frontiers in endocrinology · 2022Review
- Endocrine Autoimmunity in Pregnancy.Frontiers in immunology · 2022Review
- 2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction.European thyroid journal · 2021Article
- Autoimmune thyroid disease in infertility and assisted reproductive technology: A review.Porto biomedical journalReview
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Autoimmune thyroid disease is the most common endocrine disorder during pregnancy. Thyroid autoantibodies (TAs) have been suggested to serve a role in implantation failure and spontaneous abortion. Until now, there are no data on the potential interaction of TAs with human reproductive organs. Here, we set out for the first time to test this hypothesis by studying the expression of thyroid peroxidase (TPO) at gene and protein level in human reproductive organs. Endometrial samples were taken from normal women, and placenta tissues were collected after full-term caesarian section. Expression of TPO messenger RNA (mRNA) was investigated by qRT-PCR. In addition, polyclonal anti-TPO antibodies were produced and the expression of TPO protein in mentioned tissues was evaluated by immunohistochemistry and Western blot analysis. The reactivity of anti-TPO antibody in human embryos was evaluated by immunofluorescent staining. For the first time, our study showed that TPO is expressed at gene and protein levels in endometrium and placenta. TPO expression was mainly localized to glandular and luminal epithelial cells in the endometrium. In placenta, the syncytiotrophoblasts and invasive trophoblast cells were the main cell types that expressed TPO protein. Specific band of approximately 110 kDa was observed in all endometrial and placental tissues by Western blot analysis. However, no expression of TPO protein was observed in human embryo. TPO expression in endometrium and placenta may explain higher frequency of abortion and infertility in patients with thyroid autoimmunity.
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