Observational studyPediatric neurology2020
Characterization of Death in Infants With Neonatal Seizures.
Observational study in Pediatric neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Enhancing shared decision-making for infants in the intensive care unit: lessons from parents.Pediatric research · 2025Article
- Association of low hospital birth volume and adverse short-term outcomes for neonates treated with therapeutic hypothermia in rural states.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Neonatal mortality and survival of low-birth-weight infants at hospitals in indonesia, a multi center study.Scientific reports · 2025Article
- Feasibility of an Intervention to Support Shared Decision-Making for Critically Ill Infants.The Journal of pediatrics · 2025Article
- Time to death and its predictors among neonates with seizure in North West Ethiopia.Scientific reports · 2025Article
- Machine learning for forecasting initial seizure onset in neonatal hypoxic-ischemic encephalopathy.Epilepsia · 2025Article
- Predictors of Death or Severe Impairment in Neonates With Hypoxic-Ischemic Encephalopathy.JAMA network open · 2024Article
- Feeding and developmental outcomes after neonatal seizures-A prospective observational study.Annals of the Child Neurology Society · 2023Article
- Seminars in Fetal & neonatal medicine: Palliative and end of life care in the NICU.Seminars in fetal & neonatal medicine · 2023Review
- Effect of neonatal seizure burden and etiology on the long-term outcome: data from a randomized, controlled trial.Annals of the Child Neurology Society · 2023Article
- The ALIGN Framework: A Parent-Informed Approach to Prognostic Communication for Infants With Neurologic Conditions.Neurology · 2023Article
- Characterizing the Language Used to Discuss Death in Family Meetings for Critically Ill Infants.JAMA network open · 2022Article
- Prognostic Discussion for Infants with Neurologic Conditions: Qualitative Analysis of Family Conferences.Annals of neurology · 2022Article
- Decisional Satisfaction, Regret, and Conflict Among Parents of Infants with Neurologic Conditions.The Journal of pediatrics · 2022Article
- Neuropalliative Care for Neonates.Journal of child neurology · 2021Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundNeonatal seizures are associated with death and neurological morbidity; however, little is known about how neonates with seizures die.
methodsThis was a prospective, observational cohort study of neonates with seizures treated at seven sites of the Neonatal Seizure Registry. We characterized the mode of death, evaluated the association between infant characteristics and mode of death, and evaluated predictors of death or transfer to hospice.
resultsWe enrolled 611 consecutive neonates with seizures, and 90 neonates (15%) died before hospital discharge at a median age of 11 days (range: 1 to 163 days); 32 (36%) died in the first postnatal week. An additional 19 neonates (3%) were transferred to hospice. The most common mode of in-hospital death was death after extubation amidst concerns for poor neurological prognosis, in the absence of life-threatening physiologic instability (n = 43, 48%). Only one infant died while actively receiving cardiopulmonary resuscitation. In an adjusted analysis, premature birth (odds ratio: 3.06, 95% confidence interval 1.59 to 5.90) and high seizure burden (odds ratio: 4.33, 95% confidence interval 1.88 to 9.95) were associated with increased odds of death or transfer to hospice.
conclusionIn a cohort of neonates with seizures, death occurred predominantly after decisions to withdraw or withhold life-sustaining intervention(s). Future work should characterize how these decisions occur and develop optimized approaches to support families and clinicians caring for newborns with seizures.
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