Evidence map›Paper›PMID 32980696›Full record

Trial reportEBioMedicine2020

The exploration of optimized protocol for repetitive transcranial magnetic stimulation in the treatment of methamphetamine use disorder: A randomized sham-controlled study.

Tianzhen Chen, Hang Su, Ruihua Li, Haifeng Jiang, Xiaotong Li, Qianying Wu, Haoye Tan, Jingying Zhang, Na Zhong, Jiang Du and 2 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 6 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03736317 nacompletednot on this map

Evaluation of the Effect of Repetitive Transcranial Magnetic Stimulation in Craving in Methamphetamine Use Disorder

TypeinterventionalSponsorShanghai Mental Health CenterRan2019 to 2021Enrolled144ConditionsAmphetamine Use DisordersArmssham TBS, real mPFC cTBS, real dlPFC iTBS, real dlPFC iTBS + real mPFC cTBS
NCT06830980 nacompletednot on this mapstarted 2025, after this paper: background citation

TMS (Transcranial Magnetic Stimulation) for Methamphetamine Use Disorder in People Living With HIV

TypeinterventionalSponsorGopalkumar RakeshRan2025 to 2026Enrolled12ConditionsMethamphetamine Use Disorders, HIVArmsintermittent theta burst stimulation (iTBS), continuous theta burst stimulation (cTBS), Sham TMS
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  5. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Tianzhen Chen(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hang Su(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ruihua Li(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haifeng Jiang(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaotong Li(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qianying Wu(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haoye Tan(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jingying Zhang(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Na Zhong(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiang Du(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huijuan Gu(b)Shanghai Drug Rehabilitation Center of Public Security Bureau, Shanghai, China.
Min Zhao(a)Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; (c)Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China; (d)Institute of Psychological and Behavioral Science, Shanghai Jiao Tong University, Shanghai, China; (e)CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Sciences, Shanghai, China. Electronic address: drminzhao@smhc.org.cn.
Shanghai Jiao Tong University · CNShanghai Mental Health Center · CNCenter for Excellence in Brain Science and Intelligence Technology · CNShanghai Public Security Bureau · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prefrontal-striatal circuit is a core circuit related to substance dependence. Previous studies have found that repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC) (key region of executive network) had limited responses, while inhibiting hyperactivation of ventromedial prefrontal cortex (vmPFC) (key region of limbic network) may be another strategy. However, there is currently no comparison between these two treatment locations.

methodsSeventy-four methamphetamine-dependent patients were randomly assigned to one of treatment groups with two-week treatment: (1) Group A: intermittent theta-burst stimulation (iTBS) targeting the left DLPFC; (2) Group B: continuous theta-burst stimulation (cTBS) targeting the left vmPFC; (3) Group C: a combination of treatment protocol of Group A and Group B; (4) Group D: sham theta-burst stimulation. The primary endpoint was the change of cue-induced craving. The trial was registered at ClinicalTrials.gov (NCT03736317).

findingsThe three real TBS groups had more craving decrease effect than the sham group (p<0.01). The changes of craving were positively correlated with the improvement of anxiety and withdrawal symptom. With the highest respondence rate, group C also had shorter respondence time than Group A (p = 0.03). Group C was effective in improve depression symptoms (p = 0.04) and withdrawal symptom (p = 0.02) compared with Group D. Besides, Group C was significant in improve sleep quality (p = 0.04) compared with Group A. Baseline depression scores and spatial working memory were positively predicting the intervention response.

interpretationThe rTMS paradigms involving vmPFC with cTBS are optimized protocols and well-tolerated for methamphetamine-dependent individuals, and they may have better efficacies compared with DLPFC iTBS. Emotion and cognitive function are rTMS treatment response predictors for methamphetamine-dependent patients.

fundingThis work was supported by the National Key R&D Program of China (2017YFC1310400), National Natural Science Foundation of China (81,771,436, 81,801,319, 81,601,164), Shanghai Municipal Health and Family Planning Commission (2017ZZ02021), Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ013), Qihang Project of Shanghai Mental Health Center (2019-QH-05), Shanghai Sailing Program (19YF1442100), Shanghai Key Laboratory of Psychotic Disorders (13DZ2260500), Program of Shanghai Academic Research Leader (17XD1403300), Shanghai Municipal Science and Technology Major Project (2018SHZDZX05), and Shanghai Clinical Research Center for Mental Health (19MC1911100).

Indexed as

Transcranial Magnetic StimulationAdultAmphetamine-Related DisordersCase-Control StudiesCentral Nervous System StimulantsDisease ManagementDisease SusceptibilityFemaleHumansKaplan-Meier EstimateMaleMethamphetaminePrefrontal CortexTreatment OutcomeCentral Nervous System StimulantsMethamphetamineDorsolateral prefrontal cortexMethamphetamine use disorderOptimized treatment protocolTheta-burst stimulationVentromedial prefrontal cortex

Identifiers

PMID32980696
PMCPMC7522737
OpenAlexW3088742242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.