Evidence map›Paper›PMID 32980662›Full record

ArticleRedox biology2020

The functional significance of redox-mediated intersubunit cross-linking in regulation of human type 2 ryanodine receptor.

Roman Nikolaienko, Elisa Bovo, Robyn T Rebbeck, Daniel Kahn, David D Thomas, Razvan L Cornea, Aleksey V Zima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. ER stress and calcium-dependent arrhythmias.Frontiers in physiology · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Roman NikolaienkoDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA.
Elisa BovoDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA.
Robyn T RebbeckDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Daniel KahnDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA.
David D ThomasDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Razvan L CorneaDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Aleksey V ZimaDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA. Electronic address: azima@luc.edu.
Loyola University Chicago · USUniversity of Minnesota · US

Funding

Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
Structural Dynamics of Cardiac Muscle Calcium ATPase RegulationR01HL139065 · NHLBI · UNIVERSITY OF MINNESOTA · PI Robyn T Rebbeck, David D Thomas · 2020 to 2026
$5.2M
Site-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5M
High-Throughput Screens to Discover Novel Inhibitors of Leaky RyR2 for Heart Failure TherapyR01HL138539 · NHLBI · UNIVERSITY OF MINNESOTA · PI BERS, DONALD M, CORNEA, RAZVAN LIVIU · 2018 to 2021
$3.1M
Protein Oxidation, Structure, &Function in Aging MuscleR01AG026160 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 2004 to 2008
$2.2M
Calcium release channel dysfunction: molecular mechanismsR01HL130231 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZIMA, ALEKSEY V · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL130231NHLBI NIH HHS R01 HL138539NHLBI NIH HHS R01 HL139065NIA NIH HHS R01 AG026160NIA NIH HHS R37 AG026160
6 · The paper itself

Abstract

The type 2 ryanodine receptor (RyR2) plays a key role in the cardiac intracellular calcium (Ca

Indexed as

Calcium SignalingRyanodine Receptor Calcium Release ChannelAnimalsCalciumHEK293 CellsHumansOxidation-ReductionRabbitsCalciumRyanodine Receptor Calcium Release ChannelRyR2 protein, humanCa(2+) signalingCa(2+) wavesRyanodine receptorSarcoplasmic reticulum and oxidative stress

Identifiers

PMID32980662
PMCPMC7522892
OpenAlexW3085387879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.