ArticleNeuroImage. Clinical2020
Structural brain damage and visual disorders in children with cerebral palsy due to periventricular leukomalacia.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06672731 (BIODETECT_CP a Novel Combination of BIOchemical, DEnsitometric, TEChnological and Imaging Tools to Evaluate the Bone/muscle Unit Health in Children with Cerebral Palsy), which is not on this map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BIODETECT_CP a Novel Combination of BIOchemical, DEnsitometric, TEChnological and Imaging Tools to Evaluate the Bone/muscle Unit Health in Children with Cerebral Palsy
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Identifying and addressing gaps in recognition of cerebral/cortical visual impairment risk in the NICU.Pediatric research · 2026Article
- Ophthalmological outcomes, visual perception, fine motor precision, and visual-motor integration in children born very preterm.Developmental medicine and child neurology · 2026Article
- Birth-related characteristics predict vision-related quality of life in adults: A population-based study.PloS one · 2026Article
- Alterations in Corpus Callosum Subregion Microstructure Associated With Visual Dysfunction in Individuals With Cerebral Visual Impairment.Behavioural neurology · 2026Observational
- The effect of hemoglobin level in early life on periventricular leukomalacia: a case control study.Scientific reports · 2025Article
- Structural and functional attention network connectivity in relation to visual selective attention dysfunction in cerebral visual impairment.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Thalamic Volume Reduction in Cerebral Visual Impairment: Relationship to Visual Dysfunction.Journal of child neurology · 2025Article
- Vestibulo-Oculomotor Reflex Dysfunction in Children with Cerebral Palsy Correlates with Gross Motor Function Classification System.Audiology research · 2025Article
- Automatic brain quantification in children with unilateral cerebral palsy.Frontiers in neuroscience · 2025Article
- Visual search patterns during exploration of naturalistic scenes are driven by saliency cues in individuals with cerebral visual impairment.Scientific reports · 2024Article
- Impaired glymphatic system revealed by DTI-ALPS in cerebral palsy due to periventricular leukomalacia: relation with brain lesion burden and hand dysfunction.Neuroradiology · 2024Article
- Implications of cerebral/cortical visual impairment on life and learning: insights and strategies from lived experiences.Frontiers in human neuroscience · 2024Article
- Lesion mapping and functional characterization of hemiplegic children with different patterns of hand manipulation.NeuroImage. Clinical · 2024Article
- Motion and form coherence processing in individuals with cerebral visual impairment.Developmental medicine and child neurology · 2023Article
- White matter microstructure and receptive vocabulary in children with cerebral palsy: The role of interhemispheric connectivity.PloS one · 2023Article
- Childhood cerebral visual impairment subtype classification based on an extensive versus a limited test battery.Frontiers in neuroscience · 2023Article
- Visual Function and Neuropsychological Profile in Children with Cerebral Visual Impairment.Children (Basel, Switzerland) · 2022Article
- The Multidisciplinary Guidelines for Diagnosis and Referral in Cerebral Visual Impairment.Frontiers in human neuroscience · 2022Article
- Age-Related Effects on the Spectrum of Cerebral Visual Impairment in Children With Cerebral Palsy.Frontiers in human neuroscience · 2022Article
- Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL).Bioengineered · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo systematically explore the relationship between type and severity of brain lesion on Magnetic Resonance Imaging (MRI) and visual function in a large cohort of children with periventricular leukomalacia (PVL).
methods94 children with bilateral cerebral palsy (CP) and history of PVL were recruited at Stella Maris Scientific Institute in Pisa (Italy). We included data of participants (72) with at least one MRI after the age of three years and an evaluation of visual function including fixation, following, saccades, nystagmus, acuity, visual field, stereopsis and color perception. Brain lesions location and extent were assessed by a semi-quantitative MRI-scale for children with CP.
resultsBrain lesion severity strongly correlated with visual function total score (global MRI score p = .000; hemispheric score p = .001 and subcortical score p = .000). Moreover, visual acuity, visual field, stereopsis and colour were compromised when a cortical damage was present, while ocular motricity (and in particular fixation and saccades) were compromised in presence of subcortical brain damage.
interpretationStructural MRI is valuable for understanding the relationship between brain lesion severity and visual function in children with CP.
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