ReviewProgress in retinal and eye research2021
Zinn's zonule.
Review in Progress in retinal and eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Mutation analysis of SUOX in isolated sulfite oxidase deficiency with ectopia lentis as the presenting feature: insights into genotype-phenotype correlation.Orphanet journal of rare diseases · 2022Pooled it
- Deep Proteomic Analysis With Machine Learning Identifies Aqueous Humor Biomarkers of ADAMTSL4-associated Congenital Ectopia Lentis.Investigative ophthalmology & visual science · 2026Article
- Cataract after electrical injury: clinical characteristics and surgical management outcomes, a case report of three cases.BMC ophthalmology · 2026Article
- Bilateral anterior lens luxation with secondary glaucoma strongly associated with self-application of a percussion massage gun to closed eyelids: a case report.BMC ophthalmology · 2026Article
- Functional and anatomical outcomes of Yamane technique-based scleral fixation after complicated cataract surgery versus IOL extraction.BMC ophthalmology · 2026Article
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Gas Entrapment in the Canal of Petit During Pneumatic Retinopexy: Sequential Imaging and Conservative Management.Journal of vitreoretinal diseases · 2026Article
- Ciliary Zonule of the Human Eye: Structural and Mechanical Aspects.Investigative ophthalmology & visual science · 2026Article
- Molecular and Biomechanical Changes in the Anterior Segment of High Myopic Eyes.Annals of biomedical engineering · 2026Review
- Single zonular fiber extraction and characterization: A platform for biomechanical, biochemical and structural analyses.Experimental eye research · 2026Article
- Vitamin E Alleviates Oxidative Damage and Attenuates Ferroptosis Caused by Prolonged Contraction of the Ciliary Muscle by Activating ACOT7.Investigative ophthalmology & visual science · 2026Article
- Article
- A deep learning-based classification method for subclinical zonular laxity in AS-OCT images.Frontiers in cell and developmental biology · 2026Article
- Corneal characteristics in children with Marfan syndrome with or without ectopia lentis.Pediatric investigation · 2025Article
- Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis.Investigative ophthalmology & visual science · 2025Article
- Isolated Spherophakia and Phacodonesis in a Young Child With Short Stature: A Case Report.Cureus · 2025Article
- The Role of the Vitreous Zonule in Preoperative Diagnosis of Zonular Laxity in Primary Angle-Closure Disease.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Article
- Late Spontaneous in-the-Bag Capsular Tension Ring - Intraocular Lens - Capsular Bag Complex Subluxation in a Low-PEX Region: A Series of 31 Cases.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Establishment of a Stacking Machine Learning Model Predicting Cardiac Phenotype in Ectopia Lentis Patients Based on Genotype and Ocular Phenotype.International journal of medical sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The Zonule of Zinn, or ciliary zonule, is the elaborate system of extracellular fibers that centers the lens in the eye. In humans, the fibers transmit forces that flatten the lens during the process of disaccommodation, thereby bringing distant objects into focus. Zonular fibers are composed almost entirely of 10-12 nm-wide microfibrils, of which polymerized fibrillin is the most abundant component. The thickest fibers have a fascicular organization, where hundreds or thousands of microfibrils are gathered into micrometer-wide bundles. Many such bundles are aggregated to form a fiber. Dozens of proteins comprise the zonule. Most are derived from cells of the non-pigmented ciliary epithelium in the pars plana region, although some are probably contributed by the lens and perhaps other tissues of the anterior segment. Zonular fibers are viscoelastic cables but their component microfibrils are rather stiff structures. Thus, the elastic properties of the fibers likely stem from lateral interactions between microfibrils. Rupture of zonular fibers and subsequent lens dislocation (ectopia lentis) can result from blunt force trauma or be a sequela of other eye diseases, notably exfoliation syndrome. Ectopia lentis is also a feature of syndromic conditions caused typically by mutations in microfibril-associated genes. The resulting ocular phenotypes raise the possibility that the zonule regulates lens size and shape, globe size, and even corneal topology, in addition to its well-recognized role in accommodation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.