ArticleGastroenterology2021
Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses.
Article in Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Common auricular acupoint patterns for postoperative recovery across laparoscopic surgeries: a data mining-based systematic analysis.Frontiers in medicine · 2026Pooled it
- Aorticorenal Ganglion Ablation Enhances Blood Pressure Reduction After Renal Denervation.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Subtypes of Enteric Neurons in Hirschsprung Disease: A Comparison of Fully Ganglionic and Transitional Zone.Neurogastroenterology and motility · 2026Article
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease.Neurogastroenterology and motility · 2026Review
- Influence of Sacral and Thoracolumbar Spinal Nerve Electrical Stimulation on Colonic Motility in Anesthetized Yucatan Male Pigs.Neurogastroenterology and motility · 2026Article
- Stretchable thin-film metal electronics enabled by multilayered nanomembranes.bioRxiv : the preprint server for biology · 2025Article
- Molecular and functional diversity of the autonomic nervous system.Nature reviews. Neuroscience · 2025Review
- A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway.Nature communications · 2025Article
- Unique properties of proximal and distal colon reflect distinct motor functions.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Pharmacological characterization of alpha adrenoceptor-mediated motor responses in the rat colon.Neurogastroenterology and motility · 2025Article
- Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury.Digestive diseases and sciences · 2024Article
- Neuroimmunophysiology of the gastrointestinal tract.American journal of physiology. Gastrointestinal and liver physiology · 2024Review
- Neuroimmune Interactions in the Intestine.Annual review of immunology · 2024Review
- The parasympathetic and sensory innervation of the proximal and distal colon in male mice.Frontiers in neuroanatomy · 2024Article
- To explore the postoperative nutritional status and factors influencing prognosis in patients with chronic constipation complicated by malnutrition.Frontiers in medicine · 2024Article
- Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor αScientific reports · 2023Article
- Dysautonomia in Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2023Review
- The enteric nervous system.Physiological reviews · 2023Review
- Ion channel regulation of gut immunity.The Journal of general physiology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsThe colon is innervated by intrinsic and extrinsic neurons that coordinate functions necessary for digestive health. Sympathetic input suppresses colon motility by acting on intrinsic myenteric neurons, but the extent of sympathetic-induced changes on large-scale network activity in myenteric circuits has not been determined. Compounding the complexity of sympathetic function, there is evidence that sympathetic transmitters can regulate activity in non-neuronal cells (such as enteric glia and innate immune cells).
methodsWe performed anatomical tracing, immunohistochemistry, optogenetic (GCaMP calcium imaging, channelrhodopsin), and colon motility studies in mice and single-cell RNA sequencing in human colon to investigate how sympathetic postganglionic neurons modulate colon function.
resultsIndividual neurons in each sympathetic prevertebral ganglion innervated the proximal or distal colon, with processes closely opposed to multiple cell types. Calcium imaging in semi-intact mouse colon preparations revealed changes in spontaneous and evoked neural activity, as well as activation of non-neuronal cells, induced by sympathetic nerve stimulation. The overall pattern of response to sympathetic stimulation was unique to the proximal or distal colon. Region-specific changes in cellular activity correlated with motility patterns produced by electrical and optogenetic stimulation of sympathetic pathways. Pharmacology experiments (mouse) and RNA sequencing (human) indicated that appropriate receptors were expressed on different cell types to account for the responses to sympathetic stimulation. Regional differences in expression of α-1 adrenoceptors in human colon emphasize the translational relevance of our mouse findings.
conclusionsSympathetic neurons differentially regulate activity of neurons and non-neuronal cells in proximal and distal colon to promote distinct changes in motility patterns, likely reflecting the distinct roles played by these 2 regions.
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