SynthesisGastroenterology2021
Effect of Acid Suppressants on the Risk of COVID-19: A Propensity Score-Matched Study Using UK Biobank.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Individual risk factors associated with SARS-CoV-2 infection during Alpha variant in high-income countries: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Acid suppressant use in association with incidence and severe outcomes of COVID-19: a systematic review and meta-analysis.European journal of clinical pharmacology · 2022Pooled it
- Proton Pump Inhibitor Use Is Not Strongly Associated With SARS-CoV-2 Related Outcomes: A Nationwide Study and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Pooled it
- Article
- Temporal and Bidirectional Association Between Blood Pressure Variability and Arterial Stiffness: Cross-Lagged Cohort Study.JMIR public health and surveillance · 2023Article
- Histamine-2 Receptor Antagonists and Proton Pump Inhibitors Are Associated With Reduced Risk of SARS-CoV-2 Infection Without Comorbidities Including Diabetes, Hypertension, and Dyslipidemia: A Propensity Score-Matched Nationwide Cohort Study.Journal of Korean medical science · 2023Article
- Regular proton pump inhibitor use and incident dementia: population-based cohort study.BMC medicine · 2022Article
- Machine learning-based model for prediction of clinical deterioration in hospitalized patients by COVID 19.Scientific reports · 2022Observational
- The Use of Proton Pump Inhibitors and COVID-19: A Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2022Review
- The Association Between Proton Pump Inhibitors and COVID-19 is Confounded by Hyperglycemia in a Population-Based Study.Frontiers in pharmacology · 2022Article
- Prevention and treatment of ventilator-associated pneumonia in COVID-19.Frontiers in pharmacology · 2022Review
- Proton pump inhibitors in the COVID-19 pandemic.Gastroenterologia y hepatologia · 2021Article
- Case-control study of the association of chronic acid suppression and social determinants of health with COVID-19 infection.Scientific reports · 2021Observational
- Potential Biases in Studies of Acid-Suppressing Drugs and COVID-19 Infection.Gastroenterology · 2021Article
- Article
- A Birds-Eye (Re)View of Acid-Suppression Drugs, COVID-19, and the Highly Variable Literature.Frontiers in pharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Xiude FanDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio; Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Zhengwen LiuDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Tatsunori MiyataDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Srinivasan DasarathyDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio.
Daniel M RotroffDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Xiaoqin WuDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Kyle L PoulsenDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Laura E NagyDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio. Electronic address: nagyL3@ccf.org.
Funding
Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI JAIVIDHYA DASARATHY · 2016 to 2026
$19.6MNon Alcoholic Steatohepatitis Clinical Research NetworkU01DK061732 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2002 to 2026
$12.2MInstitutional Career Development CoreKL2TR002547 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI DWEIK, RAED A. · 2018 to 2022
$7.7MTranscriptional and non-transcriptional functions of IRF3 in ALDR01AA027456 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI LAURA E. NAGY · 2019 to 2026
$3.5MSarcopenia in cirrhosis is mediated by a hyperammonemic stress responseR01DK113196 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN, HATZOGLOU, MARIA · 2018 to 2021
$2.3MNovel therapeutics for alcoholic hepatitis - Cleveland Translational ComponentU01AA021890 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2012 to 2017
$1.6MMicrobial metabolites and Innate Immunity in AH: Biomarkers of injury and repairU01AA026938 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2018 to 2023
$1.4MMechanisms of Malnutrition in Cirrhosis with Portosystemic ShuntingR01GM119174 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN · 2017 to 2020
$1.2MHEPATOCYTE-DERIVED MIF: A KEY CONTRIBUTOR TO ALCOHOLIC LIVER DISEASER00AA026648 · NIAAA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POULSEN, KYLE · 2020 to 2022
$747kHyperammonemia reduces skeletal muscle protein synthesis via a beta-catenin-cMyc mediated impaired ribosomal biogenesisR21AR071046 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN, DAVULURI, GANGARAO · 2017 to 2018
$399kHepatocyte-derived MIF: a key contributor to Alcoholic Liver DiseaseK99AA026648 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI POULSEN, KYLE · 2018 to 2019
$258kMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCATS NIH HHS KL2 TR002547NIAAA NIH HHS K99 AA026648NIAAA NIH HHS P50 AA024333NIAAA NIH HHS R00 AA026648NIAAA NIH HHS R01 AA027456NIAAA NIH HHS U01 AA021890NIAAA NIH HHS U01 AA026938NIAMS NIH HHS R21 AR071046NIDDK NIH HHS R01 DK113196NIDDK NIH HHS U01 DK061732NIGMS NIH HHS R01 GM119174
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedCOVID-19FemaleHistamine H2 AntagonistsHumansMaleMiddle AgedPrevalencePrognosisPropensity ScoreProton Pump InhibitorsRisk AssessmentRisk FactorsTime FactorsUnited KingdomHistamine H2 AntagonistsProton Pump InhibitorsAcid SuppressantsCOVID-19OmeprazoleSusceptibility
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.