Evidence map›Paper›PMID 32980306›Full record

ArticleEnvironmental research2021

Urban air PM modifies differently immune defense responses against bacterial and viral infections in vitro.

Muhammad Ali Shahbaz, Maria-Viola Martikainen, Teemu J Rönkkö, Mika Komppula, Pasi I Jalava, Marjut Roponen

Abstract read
In one paragraph

Article in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Elevated COAllergy · 2026
    Article
  2. Association between long-term PMBMC public health · 2026
    Article
  3. Review
  4. Article
  5. Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  6. Observational
  7. Article
  8. Article
  9. Role of Macrophages in Air Pollution Exposure Related Asthma.International journal of molecular sciences · 2022
    Review
  10. Observational
  11. Article
  12. Article
  13. Mapping the Morbidity Risk Associated with Coal Mining in Queensland, Australia.International journal of environmental research and public health · 2022
    Article
  14. Role of Innate Immune System in Environmental Lung Diseases.Current allergy and asthma reports · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muhammad Ali ShahbazUniversity of Eastern Finland, Department of Environmental and Biological Sciences, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. Electronic address: ali.shahbaz@uef.fi.
Maria-Viola MartikainenUniversity of Eastern Finland, Department of Environmental and Biological Sciences, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland.
Teemu J RönkköUniversity of Eastern Finland, Department of Environmental and Biological Sciences, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland.
Mika KomppulaFinnish Meteorological Institute, Yliopistonranta 1F, P.O. Box 1627, FI-70211, Kuopio, Finland.
Pasi I JalavaUniversity of Eastern Finland, Department of Environmental and Biological Sciences, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland.
Marjut RoponenUniversity of Eastern Finland, Department of Environmental and Biological Sciences, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological evidence has shown the association between exposure to ambient fine particulate matter (PM) and increased susceptibility to bacterial and viral respiratory infections. However, to date, the underlying mechanisms of immunomodulatory effects of PM remain unclear. Our objective was to explore how exposure to relatively low doses of urban air PM alters innate responses to bacterial and viral stimuli in vitro. We used secondary alveolar epithelial cell line along with monocyte-derived macrophages to replicate innate lung barrier in vitro. Co-cultured cells were first exposed for 24 h to PM

Indexed as

Air PollutantsPneumoniaVirus DiseasesCytokinesHumansParticle SizeParticulate MatterTumor Necrosis Factor-alphaAir PollutantsCytokinesParticulate MatterTumor Necrosis Factor-alphaAmbient particulate matterLipopolysaccharidesORN R-0006Poly: ICRespiratory infectionsToll-like receptor

Identifiers

PMID32980306
PMCPMC7516585

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.