ReviewTrends in molecular medicine2021
The Ground Zero of Organismal Life and Aging.
Review in Trends in molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 74 citations in OpenAlex.
- Ferroptosis-related stress during aging and its relevance to disease.GeroScience · 2026Review
- Reversing aging-like 3D genome disorganization in abioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- Foundations of Gerophysics.Aging · 2026Article
- Molecular evolution of animal aging.The EMBO journal · 2026Review
- Mechanistic redundancy and hierarchy of aging mechanisms: implications for strategies to extend healthspan and biomarker integration.Frontiers in aging · 2026Review
- A microfluidics-based platform enables discovery of gametogenic rejuvenation factors inbioRxiv : the preprint server for biology · 2025Article
- Aging by the clock and yet without a program.Nature aging · 2025Review
- A Biophysics of Epigenetic Rejuvenation.Cells · 2025Article
- Aging and immunity: the age-old tango.Genes & development · 2025Review
- DNA methylation-based age prediction and sex-specific epigenetic aging in a lizard with female-biased longevity.Science advances · 2025Article
- Article
- Evaluation of the antioxidant and longevity-promoting effects of white tea extract inFrontiers in nutrition · 2025Article
- Epistemic uncertainty challenges aging clock reliability in predicting rejuvenation effects.Aging cell · 2024Article
- Profiling the transcriptomic age of single-cells in humans.Communications biology · 2024Article
- Aging clocks based on accumulating stochastic variation.Nature aging · 2024Article
- The beginning of becoming a human.Aging · 2024Review
- Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.eLife · 2024Article
- Utilizing epigenetics to study the shared nature of development and biological aging across the lifespan.NPJ science of learning · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cells may naturally proceed or be forced to transition to a state with a radically lower biological age, that is, be rejuvenated. Examples are the conversion of somatic cells to induced pluripotent stem cells and rejuvenation of the germline with each generation. We posit that these processes converge to the same 'ground zero', the mid-embryonic state characterized by the lowest biological age where both organismal life and aging begin. It may also be related to the phylotypic state. The ground zero model clarifies the relationship between aging, development, rejuvenation, and de-differentiation, which are distinct throughout life. By extending the rejuvenation phase during early embryogenesis and editing the genome, it may be possible to achieve the biological age at the ground zero lower than that achieved naturally.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.