Evidence map›Paper›PMID 32980261›Full record

ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2021

Review of the Endocannabinoid System.

Hui-Chen Lu, Ken Mackie

Open access · greenAbstract readReview
In one paragraph

Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
299citing papers in PubMed, 5 pooled it
31.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

299 citing papers in PubMed, 5 syntheses or guidelines pooled it, 462 citations in OpenAlex.

  1. Pooled it
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  11. Ten-year outcomes of medical cannabis for chronic low back pain: opioid reduction, pain relief, and functional improvement in 1,000 patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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239 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hui-Chen LuGill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, Indiana.
Ken MackieGill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, Indiana. Electronic address: kmackie@indiana.edu.
Indiana University Bloomington · US

Funding

Molecular and genetic studies of NMNAT2 in neuroprotectionR01NS086794 · NINDS · TRUSTEES OF INDIANA UNIVERSITY · PI LU, HUI-CHEN · 2014 to 2025
$5.0M
Perinatal cannabinoids delay KCC2 expression and lead to neurodevelopmental abnormalitiesR01DA046196 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI MACKIE, KENNETH, MANZONI, OLIVIER JJ · 2018 to 2022
$1.6M
Sex-specific critical periods determine the effects of cannabinoids on the mesocorticolimbic systemR01DA043982 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI MACKIE, KENNETH, MANZONI, OLIVIER JJ · 2017 to 2021
$1.5M
NIDA NIH HHS R01 DA043982NIDA NIH HHS R01 DA046196NINDS NIH HHS R01 NS086794
6 · The paper itself

Abstract

The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in the developing central nervous system as well as playing a major role in tuning many cognitive and physiological processes. The ECS is composed of endogenous cannabinoids, cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of endocannabinoids. In addition to its endogenous roles, cannabinoid receptors are the primary target of Δ

Indexed as

CannabisEndocannabinoidsHumansNeuronal PlasticityReceptors, CannabinoidEndocannabinoidsReceptors, CannabinoidCannabinoid receptorEndocannabinoidNeurodevelopmentPsychosisSynaptic plasticityTetrahydrocannabinol

Identifiers

PMID32980261
PMCPMC7855189
OpenAlexW3046433489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.