Evidence map›Paper›PMID 32980228›Full record

ArticleThe American journal of emergency medicine2021

Pediatric croup with COVID-19.

April M R Venn, James M Schmidt, Paul C Mullan

Open access · greenAbstract readCase Reports
In one paragraph

Article in The American journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Heliox for croup in children.The Cochrane database of systematic reviews · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. COVID-19 Associated Croup.Current pediatric reviews · 2024
    Article
  6. Outcomes of croup in children: COVID-19 versus non-COVID-19 cases.Journal of the American College of Emergency Physicians open · 2023
    Article
  7. Article
  8. Clinical Epidemiology of Pediatric Coronavirus Disease 2019 and its Postacute Sequelae.Seminars in respiratory and critical care medicine · 2023
    Review
  9. Article
  10. Review
  11. Croup and COVID-19.Journal of paediatrics and child health · 2022
    Article
  12. Croup Associated With SARS-CoV-2: Pediatric Laryngotracheitis During the Omicron Surge.Journal of the Pediatric Infectious Diseases Society · 2022
    Article
  13. [Main changes in the «COVID-19 in paediatrics» clinical practice guideline].Anales de pediatria (Barcelona, Spain : 2003) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. SARS-CoV-2 and croup, not a rare coincidence.The American journal of emergency medicine · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

April M R VennChildren's Hospital of the King's Daughters, 601 Children's Lane, Norfolk, VA, 23507, USA; Eastern Virginia Medical School, P.O. Box 1980, Norfolk, VA 23501-1980, USA; Department of Emergency Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York Presbyterian Hospital, 630 W. 168th St, New York, NY 10032, USA. Electronic address: amv2v@virginia.edu.
James M SchmidtChildren's Hospital of the King's Daughters, 601 Children's Lane, Norfolk, VA, 23507, USA; Eastern Virginia Medical School, P.O. Box 1980, Norfolk, VA 23501-1980, USA. Electronic address: James.Schmidt@chkd.org.
Paul C MullanChildren's Hospital of the King's Daughters, 601 Children's Lane, Norfolk, VA, 23507, USA; Eastern Virginia Medical School, P.O. Box 1980, Norfolk, VA 23501-1980, USA. Electronic address: Paul.Mullan@chkd.org.
Children's Hospital of The King's Daughters · USEastern Virginia Medical School · USNew York Hospital Queens · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection. All three cases (ages 11 months, 2 years, and 9 years old) presented with non-specific upper-respiratory-tract symptoms that developed into a barky cough with associated stridor at rest and respiratory distress. All were diagnosed with SARS-CoV-2 by polymerase chain reaction testing from nasopharyngeal samples that were negative for all other pathogens including the most common etiologies for croup. Each received multiple (≥3) doses of nebulized racemic epinephrine with minimal to no improvement shortly after medication. All had a prolonged period of time from ED presentation until the resolution of their stridor at rest (13, 19, and 21 h). All received dexamethasone early in their ED treatment and all were admitted. All three received at least one additional dose of dexamethasone, an atypical treatment occurrence in our hospital, due to each patient's prolonged duration of symptoms. One child required heliox therapy and admission to intensive care. All patients were eventually discharged. Pathogen testing is usually not indicated in croup, but with "COVID-19 croup," SARS-CoV-2 testing should be considered given the prognostic significance and prolonged quarantine implications. Our limited experience with this newly described COVID-19 croup condition suggests that cases can present with significant pathology and might not improve as rapidly as those with typical croup.

Indexed as

ChildChild, PreschoolComorbidityCOVID-19CroupFemaleHumansInfantMaleRNA, ViralSARS-CoV-2RNA, ViralCOVID-19CroupEmergency departmentPediatricSevere acute respiratory syndrome coronavirus 2Stridor

Identifiers

PMID32980228
PMCPMC7490245
OpenAlexW3085840571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.